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Role of kupffers cells and hepatocytes in fibrinogen catabolism






Voprosy Meditsinskoi Khimii 28(4): 83-86

Role of kupffers cells and hepatocytes in fibrinogen catabolism

Products of fibrinogen degradation were studied after incubation of the protein with Kupffer's cells and hepatocytes, isolated from rabbit liver tissue, using immunochemical procedures and polyacrylamide gel electrophoresis in presence of sodium dodecyl sulfate. The fibrinogenolysis was accompanied by a decrease in molecular mass of the protein and appearance of low molecular products of degradation, which were similar to those obtained after plasmin proteolysis of fibrinogen. An activator of plasminogen appears to be present in Kupffer's cells and hepatocytes; catabolism of fibrinogen may occur in liver tissue.


Accession: 006351331

PMID: 7113060



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