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Role of lipid free radical initiator and oxygen on the kinetics of lipid per oxidation


Toxicology & Applied Pharmacology 63(1): 21-28
Role of lipid free radical initiator and oxygen on the kinetics of lipid per oxidation
The relationship between the concentration of unsaturated lipid, free radical initiator and O2 concentration on the kinetics of lipid peroxidation was determined. The rate of lipid peroxidation was studied with the thiobarbituric acid (TBA), diene conjugation (DC) and ferrithiocyanate (Fe-SCN) methods. The rate of peroxidation was half-order with respect to unsaturated lipid, initiator and O2. The half-order relationship could be expressed as follows: rate = (fk1k2k3/k6)1/2(azobisisobutyronitrile)1/2 (RH [hydrocarbon])1/2(O2)1/2. The half-order relationship was found with linoleic (18:2), linolenic (18:3) and arachidonic (20:4) acids. A linear relationship existed between the log of unsaturation and the rate of peroxidation. No peroxidation of linolenic acid was indicated when the DC method was employed but was when the TBA and Fe-SCN methods were used.


Accession: 006351435



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