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Role of lipid per oxidation and some anti oxidants in the pathogenesis of burn disease and the effect of alpha tocopherol on its course



Role of lipid per oxidation and some anti oxidants in the pathogenesis of burn disease and the effect of alpha tocopherol on its course



Zhurnal Eksperimental'noi i Klinicheskoi Meditsiny 17(5): 68-78



Burn trauma led to increased lipid peroxidation in rat liver, accompanied by a reduction of the content of endogenous .alpha.-tocopherol and phospholipids, especially lecithins and ehtanolamine phosphatides, and a reduction of the percentage of unsaturated fatty acids in phospholipids. General and non-protein SH-groups and superoxide dismutase activity diminished considerably in the 1st days, while the permeability of the bilayer phospholipid membrane for K+ and Ca2+ ions sharply increased. I.p. administration of .alpha.-tocopherol after burn trauma in daily doses of 100 mg/kg sharply suppressed lipid peroxidation, and increased the .alpha.-tocopherol content by several times, while decreasing the phospholipid content to a larger degree than during burn trauma alone, although the survival time of the rats was shortened. The administration of 1 mg/kg .alpha.-tocopherol immediately after burning and on the 3rd, 7th, 12th and 17th days afterwards as a whole normalized the indices and prolonged the life span of the animals.

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Accession: 006351440

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