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Role of lipid per oxidation in the control of liver microsomal mono oxygenase activity in warm blooded rats exposed to cold



Role of lipid per oxidation in the control of liver microsomal mono oxygenase activity in warm blooded rats exposed to cold



Byulleten' Eksperimental'noi Biologii i Meditsiny 95(1): 37-39



The reaction rates of N-demethylation of aminopyrine, p-hydroxylation of aniline and hydroxylation of 3,4-benzo(a)pyrene in liver microsomes were determined in rats exposed to severe cold (-7.degree. C) for a long time (8 days). The data obtained demonstrate the decreased activities of 3,4-benzo(a)pyrene hydroxylase and aniline hydroxylase. There were no distinct alterations in aminopyrine N-demethylase activity. The increased levels of NADPH- and ascorbate-dependent microsomal lipid peroxidation together with impairment of the soluble antioxidant glutathione system are considered in animals exposed to cold as a possible mechanism of monooxygenase activity deterioration in liver microsomes.

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Accession: 006351442

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