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Role of macrophages in defective cell mediated immunity in lepromatous leprosy 1. factors from macrophages affecting protein synthesis and lymphocyte transformation



Role of macrophages in defective cell mediated immunity in lepromatous leprosy 1. factors from macrophages affecting protein synthesis and lymphocyte transformation



International Journal of Leprosy and Other Mycobacterial Diseases 48(2): 172-177



Macrophages from lepromatous leprosy patients specifically show reduced protein synthesis in the presence of Mycobacterium leprae. They also produce, as a result of interaction with M. leprae, factor(s) that reduce protein synthesis in normal macrophages and block lymphocyte transformation in normal leukocyte cultures in the presence of M. leprae as the antigen. These observations implicate a defective macrophage system in lepromatous leprosy patients.

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Accession: 006351632

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PMID: 7190553



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