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Safety and immunogenicity of live infectious bursal disease vaccine in chicken and immune status of breeder hens to infectious bursal disease virus



Safety and immunogenicity of live infectious bursal disease vaccine in chicken and immune status of breeder hens to infectious bursal disease virus



Research Reports of the Office of Rural Development (Suweon) 26(LIVEST AND VET): 80-84



An infectious bursal disease (IBD) live vaccine locally developed was evaluated for its safety, immunogenecity and compatibility with a Newcastle disease (ND) live vaccine in chickens. The immune status of breeder hens to IBD virus (IBDV) was examined for determining the most suitable time of vaccination in their progeny. The live IBD vaccine induced a slight bursal atrophy in chicks; however, it afforded a good immunity in chicks < 6 wk old. The vaccine could be used with the ND live vaccine simultaneously without any immunosuppressive effect. The immune status of breeder hens to IBDV was unexpectedly high. Of 270 serum samples tested, 92.6% han an IBDV neutralizing antibody titer > 10,000. The geometric mean titer calculated from 255 serum samples having an antibody titer of .gtoreq. 5000 was .apprx., 90,720. Considering the half-life of maternally-derived antibody in chicks and the lowest antibody level providing marginal protection against IBDV infection, it was presumed that .apprx. 93% of progeny could be protected from a field infection for the first 3 wk of live. It was also assumed that 50% of them could resist against a field challenge until they are 4-5 wk old. Therefore, vaccination of chicks with live IBDV may be delayed until they reach 4-5 wk of age.

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Accession: 006359967

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