Scutellariae radix 5. effects on ethanol induced hyper lipemia and lipolysis in isolated fat cells

Kimura, Y.; Kubo, M.; Kusaka, K.; Tani, T.; Higashino, M.; Arichi, S.; Okuda, H.

Chemical and Pharmaceutical Bulletin (Tokyo) 30(1): 219-222


ISSN/ISBN: 0009-2363
Accession: 006370082

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The effects of oral administration of flavonoid components of Scutellariae Radix on serum and liver lipid levels of rats treated with ethanol were investigated. Wogonin-reduced serum triglyceride level, and baicalein and baicalin, the major components of the drug, decreased total cholesterol, free cholesterol and triglyceride contents in the liver. Baicalein increased high density lipoprotein-cholesterol (HDL-ch) in the serum of ethanol-treated rats. In addition to these in vivo experiments, the actions of wogonin, baicalein and baicalin on catecholamine-induced lipolysis in isolated fat cells were investigated. The 3 flavones inhibited noradrenaline-induced lipolysis in isolated fat cells. The relationship between these in vivo and in vitro experiments was discussed.