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Search for autoantibodies to endothelial and smooth muscle cells in patients with multiple sclerosis

Search for autoantibodies to endothelial and smooth muscle cells in patients with multiple sclerosis

Acta Neuropathologica 66(2): 134-139

The blood-brain barrier (BBB) is disrupted in many of the lesions of multiple sclerosis (MS). Immunologically mediated injury to 1 of the major components of this barrier, the cerebral capillary, may play a role in the development of the lesion. The sera of 51 cases of MS were examined for the presence of autoantibodies to endothelial and smooth muscle cells, using the indirect immunofluorescent technique. Results were compared to those in other groups of patients with neuroimmunological disorders. No anti-endothelial cell antibodies, but antoantibodies to vascular smooth muscle were detectable in 31% of the MS sera tested. They were also present, however, in 30% of sera from cases of myasthenia gravis and in the serum of 1 of 12 cases of polymyositis. It is considered to be unlikely that antibodies to vascular tissues play any pathogenetic role in MS.

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Accession: 006370466

Download citation: RISBibTeXText

PMID: 3874512

DOI: 10.1007/bf00688688

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