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Secretory immunoglobulin a in immunological diseases of infants and children 2. salivary immunoglobulin a levels in patients with bronchial asthma



Secretory immunoglobulin a in immunological diseases of infants and children 2. salivary immunoglobulin a levels in patients with bronchial asthma



Japanese Journal of Allergology 34(2): 122-127



To clarify the role of the local immunity in bronchial asthma, the levels of s-IgA, Ig and albumin (Alb) in saliva from 66 patients (male 39 and female 27 cases), who ranged in age from 5 yr to 15 yr were measured. Of the subjects examined, 20 were saliva in asthmatic attack and 46 were saliva in non-asthmatic attack. The levels of s-IgA were measured by radioimmunoassay method. The levels of IgG, IgA and IgM were measured by single radial immunodiffusion, the levels of IgE were determined by paper radioimmunosorbent test and levels of albumins also by spectrophotometry. IgG/Alb ratio in saliva of healthy children (control group) was 0.95 .+-. 0.40, IgA/Alb ratio 144 .+-. 0.57, and s-IgA/Alb ratio 0.64 .+-. 0.37, .apprx. 3:4:2. Salivary IgM levels in control group were below 1.0 mg/dl in all of these cases. There was no significant difference in salivary IgG/Alb or IgA/Alb ratios between asthmatic children and controls. Threre was no significant difference in salivary IgG/Alb or IgA/Alb ratios between non-attack cases and attack cases. Salivary IgM levels in asthmatic children were below 1.0 mg/dl in 85% (39/46 cases) of non-attack cases and in 70% (14/20 cases) of attack cases. Salivary IgE/Alb ratios in asthmatic children were high in 11 of 46 non-attack cases (24%) and in 10 of 20 attack cases (50%). There was no correlation between the levels of serum IgE and salivary IgE in asthmatic children. There was no significant difference in salivary s-IgA/Alb ratios between non-attack cases and attack cases, but salivary s-IgA/Alb ratios in asthmatic children were lower than those in control group (P < 0.1). Thus, asthmatic children may be associated with the hypofunction of the local immunity in oral cavity.

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Accession: 006377288

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