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Selection of active strain of streptoverticillium griseocarneum var bleomycini producing bleomycetin a new anti tumor antibiotic

Selection of active strain of streptoverticillium griseocarneum var bleomycini producing bleomycetin a new anti tumor antibiotic

Antibiotiki 25(12): 887-891

Selection of the organism producing bleomycin, a multicomponent antitumor antibiotic, was performed. The aim was the selection of a more active strain with preferable synthesis of component A5 (bleomycetin) of the bleomycin complex. Optimal variants of the conditions for mutagenesis with UV light and .gamma.-rays in step-wise selection of the active strain were determined and a possibility of selecting analog-resistant mutants with the use of structural analogs of the metabolites participating in synthesis of the bleomycin molecule was studied. A mutant analog-resistant strain capable of supersynthesis of bleomycin A5 (bleomycetin) was selected, the biosynthetic capacity of S. griseocarneum var. bleomycini being increased at least 19 times.

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Accession: 006380884

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