EurekaMag.com logo
+ Site Statistics
References:
53,623,987
Abstracts:
29,492,080
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Selection of active strain of streptoverticillium griseocarneum var bleomycini producing bleomycetin a new anti tumor antibiotic



Selection of active strain of streptoverticillium griseocarneum var bleomycini producing bleomycetin a new anti tumor antibiotic



Antibiotiki (Moscow) 25(12): 887-891



Selection of the organism producing bleomycin, a multicomponent antitumor antibiotic, was performed. The aim was the selection of a more active strain with preferable synthesis of component A5 (bleomycetin) of the bleomycin complex. Optimal variants of the conditions for mutagenesis with UV light and .gamma.-rays in step-wise selection of the active strain were determined and a possibility of selecting analog-resistant mutants with the use of structural analogs of the metabolites participating in synthesis of the bleomycin molecule was studied. A mutant analog-resistant strain capable of supersynthesis of bleomycin A5 (bleomycetin) was selected, the biosynthetic capacity of S. griseocarneum var. bleomycini being increased at least 19 times.

(PDF 0-2 workdays service: $29.90)

Accession: 006380884

Download citation: RISBibTeXText



Related references

Obtaining a productive strain of Streptoverticillium griseocarneum var. bleomycini that yields the new antineoplastic antibiotic, bleomycetin. Antibiotiki 25(12): 887-891, 1980

Results of clinical trials of bleomycetin anti tumor antibiotic. Antibiotiki (Moscow) 27(12): 936-941, 1982

Preparation of a new producer of the anti tumor antibiotic bleomycetin bleomycin a 5. Vestnik Akademii Meditsinskikh Nauk SSSR (6): 57-60, 1981

Preliminary results of clinical trials of the anti tumor antibiotic bleomycetin. Antibiotiki (Moscow) 27(3): 205-206, 1982

Clinical estimation of bleomycetin an anti tumor antibiotic of the bleomycin group. Antibiotiki (Moscow) 27(5): 372-377, 1982

Streptoverticillium alboreticuli var kokandum new variety an organism producing kokandomycin a new anti fungal pentaene antibiotic. Antibiotiki (Moscow) 22(1): 7-13, 1977

Taxonomic observations on Streptoverticillium griseocarneum. Revista do Instituto de Antibioticos, Universidade Federal de Pernambuco 14(1-2): 73-82, 1974

Streptoverticillium griseoviridum new species an organism producing the anti fungal heptenoic nonaromatic antibiotic o 185 of the candidin amphotericin b group. Antibiotiki (Moscow) 23(2): 143-148, 1978

Antibiotic producing ability of a Streptoverticillium sp. Journal of Mycology & Plant Pathology 28(3): 300-307, 1998

APHE-3 and APHE-4, two new pyrazoloisoquinolinone antibiotics produced by Streptoverticillium griseocarneum NCIMB 40447. Journal of Antibiotics 49(7): 700-702, 1996

A novel Streptoverticillium cinnamoneum var scleroticum producing a polyene antibiotic. World Journal of Microbiology & Biotechnology 14(5): 705-709, 1998

Characterization of Streptoverticillium ehimense strain 388 & its antibiotic. Indian Journal of Experimental Biology 15(7): 534-537, 1977

A new antibiotic k 52a produced by streptoverticillium roseoverticilliatum ssp albosporum strain k 52. Agricultural and Biological Chemistry 40(8): 1587-1591, 1976

Selection and identification of chitosanase producing strain and antibiotic characterization. 2007