EurekaMag.com logo
+ Site Statistics
References:
53,214,146
Abstracts:
29,074,682
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Selection of an animal model for implant fixation studies: anatomical aspects


Yale Journal of Biology and Medicine 55(2): 113-122
Selection of an animal model for implant fixation studies: anatomical aspects
A number of different animal models have been employed by investigators to study the biology of the bone-cement interface as it relates to the problem of hip implant loosening in humans. This study compares to the human three species (baboon, dog, and sheep) currently under use as experimental animal models from an anatomical point of view. A number of parameters, important for the dimensional design of a femoral prosthesis, loads at the hip joint and its subsequent performance, were used for comparing external and internal femoral anatomy. The baboon and dog femora were found to be most similar to the human femur in their external anatomy. The quantification of cancellous bone distribution within the medullary canal revealed that, of the species studied, the sheep femur provided the least support to the prosthesis. The results suggest that the dog and baboon are anatomically appropriate for studying hip implant biomechanics experimentally. Thus, from an anatomical point of view, the current extensive use of the dog as an experimental animal appears appropriate.

(PDF 0-2 workdays service: $29.90)

Accession: 006380901

PMID: 7136007



Related references

Quantitative anatomical comparison of human baboon dog and sheep femora suitability for implant fixation studies. Journal of Biomechanics 14(7): 491, 1981

A new animal model for implant-related infected non-unions after intramedullary fixation of the tibia in rats with fluorescent in situ hybridization of bacteria in bone infection. Bone 48(5): 1146-1153, 2011

Anatomical fixation implant. Official Gazette of the United States Patent & Trademark Office Patents 1251(1), Oct 2, 2001

Bone allograft and implant fixation tested under influence of bio-burden reduction, periosteal augmentation and topical antibiotics. Animal experimental studies. Danish Medical Journal 61(1): B4720-B4720, 2014

Characterization of bone-implant fixation using modal analysis: application to a press-fit implant model. Journal of Biomechanics 42(11): 1643-1649, 2009

The effects of implant surface roughness and surgical technique on implant fixation in an in vitro model. Clinical Oral Implants Research 17(2): 172-178, 2006

Bone turnover markers correlate with implant fixation in a rat model using LPS-doped particles to induced implant loosening. Journal of Biomedical Materials Research. Part A 100(4): 918-928, 2012

Implant fixation strength and osseointegration following systemic administration of recombinant factor XIII and factor XIII concentrate. Animal experiment with implant fixation strength and osseointegration of porous surface implants. Zeitschrift für Orthopadie und Ihre Grenzgebiete 133(5): 394-400, 1995

Some anatomical aspects of susceptible and resistant swederape varieties in the course of development of neck necrosis; their possible utilization in genetic selection studies. International conference on oil rape, Paris, 26-30 May, 1970. 289-292, 1970

Selection of the animal model for toxicological studies. Journal of Clinical Chemistry & Clinical Biochemistry 25(12): 876, 1987