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Selection of an experimental unit in rat caries studies

Journal of Dental Research 55(3): 476-480

Selection of an experimental unit in rat caries studies

In two separate experiments, none of the 14 subunits examined consistently ranked dentifrices similarly to the ranking obtained when the individual rat was used as the experimental unit. Arbitrarily dividing the rat into subunits and then comparing results among these subunits may lead to false conclusions since the rankings using subunits vary within each experiment and from experiment to experiment.

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Accession: 006380903

PMID: 1063760

DOI: 10.1177/00220345760550032901

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