Sequential changes of alpha anti trypsin after surgical trauma

Lamy, Y.; Ibrahim, S.; Lomanto, C.; Dombrowiecki, A.

Clinica Chimica Acta 89(3): 387-392


ISSN/ISBN: 0009-8981
Accession: 006394626

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.alpha.1-Antitrypsin, an acute phase reactant, is known to rise following surgery. A study on a large group of surgical patients confirms the rise, but also shows that a significant drop in .alpha.1-antitrypsin levels occurs prior to the increase, if the serum samples are obtained immediately after completion of surgery. The observed decrease was independent of age, sex, type of surgery performed or the anesthetic administered. The decrease in serum levels may be the result of migration of .alpha.1-antitrypsin to the tissues injured during surgery.