+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Serial fecal oral transmission of hepatitis a virus in marmosets saguinus labiatus establishment of an experimental model for a natural transmission pathway of hepatitis a virus



Serial fecal oral transmission of hepatitis a virus in marmosets saguinus labiatus establishment of an experimental model for a natural transmission pathway of hepatitis a virus



Acta Medica Nagasakiensia 30(1-3): 75-92



Hepatitis A virus (HAV) originally obtained from stool specimens of a human patient with an acute phase of hepatitis type A was successively passaged in marmosets, S. labiatus by oral administrations. The pattern of infection was as follows: after a certain incubation period, the appearance of HAV antigen in stools was the first sign of infection, followed by the simultaneous elevations of transaminases and anti-HAV antibody with approximately 10-day intervals. This sequence was consistently observed throughout four successive passages. More passages resulted in less incubation time: the incubation period at passage 3 was 49 and 35 days in two animals, and those at passage 4 and 5 were 26 and 21 days, respectively. Because the inoculation dosis used beyond passage 2 was adjusted at 2,000 antigen units, the shorter incubation period in later passages suggested the adaptation of HAV in marmosets, S. labiatus. Since the adapted virus showed reproducible incubation periods as well as clinical courses in marmosets, it is now possible to look for the primary target organs other than the liver of HAV, if any, and to use this system for the screening of vaccine candidates.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 006395637

Download citation: RISBibTeXText


Related references

Exposure to 60 hertz electric and magnetic fields alters biogenic amine metabolite concentrations in non human primate cerebrospinal fluid. 1985

Plasmapheresis and lymphopheresis. Ziff, M , G P Velo And S Gorini (Ed ) Advances in Inflammation Research, Vol 3 Rheumatoid Arthritis; Meeting, Verona, Italy, Oct 20-22, 1980 Xv+350p Raven Press: New York, N Y , Usa Illus P271-284, 1982

Hepatitis A virus in stool during clinical relapse. Annals of Internal Medicine 106(2): 221-226, 1987

Molecular evidence against phylogenetically distinct host races of the pea aphid Acyrthosiphon pisum. Genome 41(6): 769-775, 1998

Effect of house officer clerking on short-term outcomes in paediatric orthopaedic patients. New Zealand Medical Journal 130(1453): 46-49, 2017

Fecal alpha-1-antitrypsin excretion in acute diarrhea: relationship with causative pathogens. Helvetica Paediatrica Acta 43(3): 211-218, 1988

Transfusion thresholds and red blood cells transfusion focused on tissue oxygenation. Revista Espanola de Anestesiologia Y Reanimacion 65(7): 363-365, 2018

Various physico-chemical properties of lytic proteinase L2 of the enzyme preparation lysoamidase isolated from bacteria of Pseudomonadaceae family. Biokhimiia 51(6): 909-915, 1986

More ballast!. BMJ 289(6454): 1308-1308, 1984

More complex pharmacy tasks accent the computer potential. Modern Hospital 107(4): 146, 1966

Prevalence and epidemiology of unsuspected onychomycosis in patients visiting dermatologists' offices in Ontario, Canada - a multicenter survey of 2001 patients. International Journal of Dermatology 36(10): 783-787, 1997

Hepatitis C viral infection in thalassemic children: clinical and molecular studies. Pediatric Research 39(2): 323-328, 1996

Vertical transmission of hepatitis b the necessity providing immunoprophylaxis to household contacts. Paediatrie und Paedologie 20(4): 393-396, 1985

Human immunodeficiency virus infection and hepatitis C pathology. Liver 14(6): 314-319, 1994

Studies on the prevention of type 1 diabetes mellitus immunosuppression of pancreatic insulitis in nod mice. Medical Journal of Kobe University 48(2): 1-12, 1987