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Serum immuno reactive calcitonin in low birth weight infants description of early changes effect of intra venous calcium infusion relationships with early changes in serum calcium phosphorus magnesium parathyroid hormone and gastrin levels



Serum immuno reactive calcitonin in low birth weight infants description of early changes effect of intra venous calcium infusion relationships with early changes in serum calcium phosphorus magnesium parathyroid hormone and gastrin levels



Pediatric Research 15(5): 803-808



The present studies were designed to gain more information on neonatal hypercalcitoninemia and its relationships with the early changes of Ca metabolism of the low birth weight (LBW) infants. In a 1st study, serum immunoreactive calcitonin (iCT) levels and serum Ca, phosphorus (P), magnesium (Mg), and immunoreactive parathyroid hormone (iPTH) levels were measured at regular intervals (cord, 2, 5, 8 and 12 h of life) in 12 LBW infants (group 1). In the cord, moderately elevated serum iCT levels were observed; in the great majority of the infants, a slight decrease in serum iCT levels occurred 2 h after birth followed by a clear-cut increase reaching nadir values at 8 or 12 h. There was a marked decrease in serum Ca levels between birth and 8 h. In most infants, a sustained increase in serum iPTH was observed from birth to 12 h. Serum Mg and P levels were not changed. Serum iCT levels were negatively correlated with gestational age at 5, 8 and 12 h and with serum Ca levels at 8 h. Positive correlations between serum iCT and serum iPTH levels were found at 8 and 12 h. In a 2nd study, 8 LBW infants received a continuous Ca infusion (70 mg/kg) 2-12 h to maintain a Ca supply corresponding to the daily fetal Ca intake. Serum iCT levels and serum Ca, P, Mg, iPTH and immunoreactive gastrin (i gastrin) levels were determined at 2 and 12 h. There were no differences at 2 h in serum iCT, Ca, P, Mg and iPTH levels between these infants and those from group 1. At the end of the Ca infusion, serum Ca levels increased in all 8 infants reaching upper normal or above normal range values; serum P and serum iPTH levels were significantly lower than those found in group 1. The rise in serum iCT level was similar to that observed in group 1. Serum Mg and i gastrin levels were unchanged. Evidence obtained from these studies indicates that serum iCT levels in LBW infants are characterized by rapid increase starting between 2 and 5 h of life. The extent of this increase is inversely related to gestational age and is not modified when the early fall in serum Ca is prevented by large Ca infusion. The elevated serum iCT levels may contribute to the early decrease in serum Ca and thereby indirectly to the early increase in serum iPTH levels. There is apparently no relation between hypercalcitoninemia and the elevated serum i gastrin levels during the early neonatal period.

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Accession: 006401842

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PMID: 7243379


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