Section 7
Chapter 6,403

Serum lactate dehydrogenase isozyme spectrum in patients with malignant tumors

Gar'kavyi, M.I.; Kovner, F.Y. ; Narbutene, G.L.

Voprosy Onkologii (Stsburg). 24(1): 34-38


ISSN/ISBN: 0507-3758
Accession: 006402117

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The serum lactate dehydrogenase isoenzyme spectrum was studied in 170 patients with malignant and benign tumors, chronic inflammatory lesions and healthy persons. The characteristic changes in patients with malignant tumors were as follows: an increased activity of slow fractions and decreased activity in rapidly migrating fractions. The level of isoenzyme 5 activity and the frequency of its increased activity in serum correlated well with the degree of cancer spread. The determination of the percent content of the isoenzyme may be used as a supplementary test for diagnosing metastatic involvement of the liver. Examination of the serum lactate dehydrogenase isoenzyme spectrum in patients with benign tumors and chronic inflammatory disease revealed no changes characteristic of malignant neoplasms.

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