EurekaMag
+ Most Popular
Cunninghamia lanceolata plantations in China
Mammalian lairs in paleo ecological studies and palynology
Studies on technological possibilities in utilization of anhydrous milk fat for production of recombined butter-like products
Should right-sided fibroelastomas be operated upon?
Large esophageal lipoma
Apoptosis in the mammalian thymus during normal histogenesis and under various in vitro and in vivo experimental conditions
Poissons characoides nouveaux ou non signales de l'Ilha do Bananal, Bresil
Desensitizing efficacy of Colgate Sensitive Maximum Strength and Fresh Mint Sensodyne dentifrices
Administration of fluid by subcutaneous infusion: revival of a forgotten method
Tundra mosquito control - an impossible dream?
Schizophrenia for primary care providers: how to contribute to the care of a vulnerable patient population
Geochemical pattern analysis; method of describing the Southeastern limestone regional aquifer system
Incidence of low birth weights in a hospital of Mexico City
Tabanidae
Graded management intensity of grassland systems for enhancing floristic diversity
Microbiology and biochemistry of cheese and fermented milk
The ember tetra: a new pygmy characid tetra from the Rio das Mortes, Brazil, Hyphessobrycon amandae sp. n. (Pisces, Characoidei)
Risk factors of contrast-induced nephropathy in patients after coronary artery intervention
Renovation of onsite domestic wastewater in a poorly drained soil
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Systolic blood pressure in a population of infants in the first year of life: the Brompton study
Haematological studies in rats fed with metanil yellow
Studies on pasteurellosis. I. A new species of Pasteurella encountered in chronic fowl cholera
Dormancy breaking and germination of Acacia salicina Lindl. seeds
therapy of lupus nephritis. a two-year prospective study

Sheep major histocompatibility complex ola gene frequencies in 2 french breeds with scrapie evidence for a linkage between ola and resistance or susceptibility to the disease


Sheep major histocompatibility complex ola gene frequencies in 2 french breeds with scrapie evidence for a linkage between ola and resistance or susceptibility to the disease



Immunogenetics 21(2): 117-124



ISSN/ISBN: 0093-7711

Gene frequencies of 13 sheep lymphocyte factors (11 factors controlled by the sheep OLA complex including 3 closely linked loci, and 2 factors by 2 minor loci) were compared in 189 sheep of 2 breeds: (a) infected with scrapie, (b) healthy in a contaminated environment, and (c) normal. In a and c, OLA gene frequencies were similar. In healthy sheep in a contaminated environment (b), some OLA gene frequencies were higher in one breed and lower in the other. In each breed, 3 antigens had their frequencies significantly modified; 2 of them were the same in the 2 breeds, but they showed an inverse variation. The relative risk of clinical scrapie decreased in one breed and increased in the other for the same OLA gene. Apparently, OLA antigens are not directly involved in causing scrapie, and the OLA complex is linked to at least 1 scrapie resistance/susceptibility locus. In practice, it should be possible to select more resistant sheep, using some OLA antigens but an investigation of the OLA genes and the resistance to scrapie in a given breed is necessary before the selection.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 006409866

Download citation: RISBibTeXText

Related references

Sheep major histocompatibility complex OLA: gene frequencies in two French breeds with scrapie. Evidence for a linkage between OLA and resistance or susceptibility to the disease. Immunogenetics 21(2): 117-123, 1985

Sheep major histocompatibility (OLA) complex: linkage between a scrapie susceptibility/resistance locus and the OLA complex in Ile-de-France sheep progenies. Immunogenetics 27(1): 1-11, 1988

Allele frequencies of the PrP gene in 29 French sheep Breeds. Possible use in selection for resistance to scrapie. Proceedings of the 7th World Congress on Genetics Applied to Livestock Production, Montpellier, France, August, 2002 Session 13: 1-4, 2002

The sheep OLA major histocompatibility complex. Comparative gene frequencies in healthy Prealpes sheep and those with scrapie. Comptes Rendus de l' Academie des Sciences, III Sciences de la Vie 298(11): 305-308, 1984

The OLA major histocompatibility complex of sheep. Genetic frequencies compared in Prélpe sheep with and without scrapie. Comptes Rendus de l'Academie des Sciences. Serie Iii Sciences de la Vie 298(11): 305-308, 1984

The sheep ola major histocompatibility complex compared genic frequencies in normal prealpe sheep and those affected with scrapie. Comptes Rendus de l'Academie des Sciences Serie III Sciences de la Vie 298(11): 305-308, 1984

Major histocompatibility complex DRB1 gene: its role in nematode resistance in Suffolk and Texel sheep breeds. Parasitology 131(Pt 3): 403-409, 2005

Chagas' disease susceptibility/resistance: linkage disequilibrium analysis suggests epistasis between major histocompatibility complex and interleukin-10. Tissue Antigens 64(1): 18-24, 2004

Frequencies of PrP genotypes and their implication for breeding against scrapie susceptibility in nine Pakistani sheep breeds. Molecular Biology Reports 36(3): 561-565, 2009

Major OLA histocompatibility complex of sheep. Frequency of factors in sheep affected by trembling (scrapie) or normal sheep. Comptes Rendus des Seances de l'Academie des Sciences. Serie Iii Sciences de la Vie 294(2): 87-89, 1982

The diversity of major histocompatibility complex class II DRB1 gene in sheep breeds from Xinjiang, China. Tissue Antigens 85(1): 50-57, 2015

Identification of genetic variation in the major histocompatibility complex gene region in Turkish sheep breeds. South African Journal of Animal Science 46(4): 366-372, 2016

Genetic characterization of some Turkish sheep breeds based on the sequencing of the Ovar-DRB1 gene in the major histocompatibility complex (MHC) gene region. Archives Animal Breeding 61(4): 475-480, 2018

Genetic characterization of some Turkish sheep breeds based on the sequencing of the Ovar-DRB1 gene in the major histocompatibility complex (MHC) gene region. Archives Animal Breeding 61(4): 475-480, 2018

Breeding for scrapie resistance using PrP genotyping in the French dairy sheep breeds. Proceedings of the 7th World Congress on Genetics Applied to Livestock Production, Montpellier, France, August, 2002 Session 13: 1-4, 2002