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Short term toxicity of furfuryl mercaptan in rats



Short term toxicity of furfuryl mercaptan in rats



Food and Cosmetics Toxicology 15(5): 383-388



Groups of 15 rats of each sex were given daily doses of 0, 1, 3 or 30 mg furfuryl mercaptan[a flavoring constituent added to foods]/kg by stomach tube for 13 wk. No effects attributable to treatment were apparent in the analysis of urine or serum, in renal function tests or in the histological examination. At the highest dose level, a decrease in body-weight gain was associated with a reduced food intake, and there were many differences in organ [brain, heart, liver, spleen, kidney, stomach, small intestine, cecum, adrenal glands, gonads, pituitary, thyroid, lung, lymph nodes, salivary glands, trachea, esophagus, colon, rectum, spinal cord, pancreas, skeletal muscle, urinary bladder, uterus, prostate, seminal vesicles, bone marrow] weights. These consisted mainly of reduced absolute weights together with increased relative values and were thought to be associated with the lower body weights. There were some increases in Hb concentration and packed cell volume at the highest dose level, but these were not considered to represent a toxic effect. The results of this study indicate a no-untoward-effect level of 3 mg/kg per day, although in view of the nature of the findings at 30 mg/kg per day, the actual level seems likely to be higher.

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Accession: 006412113

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PMID: 598789



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