EurekaMag.com logo
+ Site Statistics
References:
48,253,228
Abstracts:
22,798,842
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Simulated respiratory system for in vitro evaluation of 2 inhalation delivery systems using selected steroids


, : Simulated respiratory system for in vitro evaluation of 2 inhalation delivery systems using selected steroids. Journal of Pharmaceutical Sciences 67(10): 1428-1431

A simulated respiratory system was developed for the in vitro evaluation of 2 differently designed oral inhalation delivery systems. The deposition properties of a newly designed delivery system used for triamcinolone acetonide were compared to the more conventional, commercially available adapter utilized for an aerosol containing beclomethasone dipropionate. The simulated respiratory system was constructed so that the delivered dose of active ingredient was classified into 2 fractions: the fraction that was deposited in the oral cavity and throat and the fraction that would reach the desired site of activity in the respiratory tract. Based on this method, the newly designed system delivered more than 95% of the labeled dose to the desired site. The beclomethasone dipropionate aerosol system, which was observed to discharge the active ingredient with a greater intensity, delivered approximately 40% of the labeled dose. The particle-size distribution of the dose dispensed from the newly designed delivery system attached to the triamcinolone acetonide aerosol was determined using an impactor technique. No effort was made to correlate these results with an in vivo response.

(PDF 0-2 workdays service)

Order PDF Full Text

Close
Close

Click here to order any other PDF Full Text


Accession: 006418211

PDF Full Text: Submit


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Other references

Mancini R.; Jezequel A.M.; Paolucci F.; Benedetti A.; Orlandi F., 1991: Quantitative analysis of proliferating desmin positive and desmin negative perisinusoidal cells in fibrotic rat liver. Gastroenterology 100(5 PART 2): A771

Yoshida M.; Hoshii H., 1982: Nutritive value of new type of chlorella for poultry feed. A sample of a new-type of chlorella, C. vulgaris Al-25, contained 24.38% of crude protein but 52.96% of N-free extracts. Available energy of the sample to growing chicks was 3.34 kcal/g with availability of 73%. Gross protein value with supplement...

Mane-Garzon, F.; Holcman Spector, B., 1973: Trematodos de las tortugas del Uruguay. 10. Telorchis achavali n.sp. del intestino delgado de Pseudemys dorbignyi (D. & B.). Revista. Biol Uruguay, 11: 5-9

Hartge, K. H., 1978: Structural stability as a function of some soil properties. The hydraulic conductivity of columns of a sandy soil has been measured under a small pressure gradient (< 0.3), before (K1) and after (K2) a short period of flow under a pressure gradient in the range 0.8 to 24. The ratio K2/K1 decreased both...

Burke, C.W., 1969: Accurate measurement of steroid-protein binding by steady-state gel filtration. Biochimica et Biophysica Acta 176(2): 403-413

Mackenzie, I.M.J.; Tunnicliffe, B., 2011: Blast injuries to the lung: epidemiology and management. Lung injury is frequently a component of the polytrauma sustained by military personnel surviving blast on the battlefield. This article describes a case series of the military casualties admitted to University Hospital Birmingham's critical...

RABOTNOV, T.A., 2014: Method of investigation on the struggle for survival in phytocoenosis; discussion on Bykov's article. Biulleten' Moskovskogo Obshchestva Ispytatelei Prirody. Otdel Biologicheskii 56(2): 74-78

Yamada, R.; Kozono, M.; Ohmori, T.; Morimatsu, F.; Kitayama, M., 2006: Simultaneous determination of residual veterinary drugs in bovine, porcine, and chicken muscle using liquid chromatography coupled with electrospray ionization tandem mass spectrometry. A simple and rapid method using liquid chromatography coupled with electrospray ionization tandem mass spectrometry (LC/MS/MS) for the simultaneous determination of 130 veterinary drugs and their metabolites in bovine, porcine, and chicken muscle...

Venkatachalam, T.K.; D'Cruz, O.J.; Uckun, F.M., 2000: Importance of the alanine methyl ester side chain for the biological activity profile of dual-function phenyl phosphate derivatives of bromo-methoxy-zidovudine. In a systematic search for developing a virucidal spermicide with potent anti-human immunodeficiency virus (HIV) and spermicidal activities, we synthesized and evaluated 14 phosphoramidate derivatives of 5-bromo-6-methoxy-zidovudine (PP-BMZ) with...

Resende, L.Macedo.de.; Ferreira, J.Dos.Santos.; Carvalho, S.Alves.da.Silva.; Oliveira, I.Simas.; Bassi, I.Barreto., 2012: Tympanometry with 226 and 1000 Hertz tone probes in infants. This study aimed at describing and analyzing tympanometric results obtained with 226 Hz and 1000 Hz probe tones; checking for correlations between tympanometry, otoacoustic emissions and otoscopic examination; describing abnormal results found in...