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Simulation of hippocampal afterdischarges synchronized by electrical interactions

, : Simulation of hippocampal afterdischarges synchronized by electrical interactions. Neuroscience 14(4): 1033-1038

Hippocampal pyramidal cells can generate synchronized action potentials even when chemical synapses are blocked. Computer simulations showed that communication between cells by extracellular currents could cause this synchrony, provided that individual neurons were sufficiently excitable and that the resistivity of the extracellular medium was sufficiently high. Synchronization was enhanced if electrotonic junctions were also present.

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Accession: 006418524

PMID: 2987752

DOI: 10.1016/0306-4522(85)90274-X

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