+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Simulation of tumor growth initiation in constantly renewing cell systems

Voprosy Onkologii (St Petersburg) 30(5): 74-80

Simulation of tumor growth initiation in constantly renewing cell systems

A discrete stochastic model simulating a cell renewal system is discussed. The model is based on a functional approach to the present-day concepts on the nature of process of cell proliferation and differentiation as well as mechanisms responsible for integration of these processes. Due to application of specialized programming means of simulation (language GPSS/360) a complete functional pattern of maintenance of cell-population homeostastis in tissue was reproduced. Disturbances in certain mechanisms of intra-tissue regulatory system accompanied by formation of tumor growth foci were simulated experimentally.

(PDF 0-2 workdays service: $29.90)

Accession: 006418781

Related references

Simulation modeling of the initiation of tumor growth in continually renewed cell systems. Voprosy Onkologii 30(5): 74-80, 1984

Simulation of self renewing systems. Jantsch, Erich And Conrad Hngton (ed.). Evolution And Consciousness. Human Systems In Transition. Xii 259p. Illus. Addison-Wesley Publishing Company: Reading, Mass., Usa; London, England. Isbn 0-201-03438-7(cloth); Isbn 0-201-03439-5(paper). 150-165, 1976

NRF2 Intensifies Host Defense Systems to Prevent Lung Carcinogenesis, but After Tumor Initiation Accelerates Malignant Cell Growth. Cancer Research 76(10): 3088-3096, 2016

Half or more of the somatic mutations in cancers of self-renewing tissues originate prior to tumor initiation. Proceedings of the National Academy of Sciences of the United States of America 110(6): 1999-2004, 2013

Evidence for self-renewing lung cancer stem cells and their implications in tumor initiation, progression, and targeted therapy. Cancer Metastasis Reviews 29(1): 61-72, 2010

Protein synthesis initiation in eukaryotic cells a comparative study of the mechanism of peptide chain initiation using cell free systems from mouse ascites tumor cells and rabbit reticulocytes. Archives of Biochemistry and Biophysics 184(2): 328-335, 1977

Constantly responsible, constantly worried, constantly blessed: parenting after pediatric heart transplant. Progress in Transplantation 19(2): 122-127, 2009

A hierarchy of self-renewing tumor-initiating cell types in glioblastoma. Cancer Cell 17(4): 362-375, 2010

Modeling hormone dependent cell cell interactions in tumor growth a simulation study. Periodicum Biologorum 93(4): 649-656, 1991

A computer analysis of the role of oxygen in the modification of radiosensitivity of self-renewing cell systems. Radiology 101(3): 683-693, 1971