+ Translate

Simulation of tumor growth initiation in constantly renewing cell systems

, : Simulation of tumor growth initiation in constantly renewing cell systems. Voprosy Onkologii (St Petersburg) 30(5): 74-80

A discrete stochastic model simulating a cell renewal system is discussed. The model is based on a functional approach to the present-day concepts on the nature of process of cell proliferation and differentiation as well as mechanisms responsible for integration of these processes. Due to application of specialized programming means of simulation (language GPSS/360) a complete functional pattern of maintenance of cell-population homeostastis in tissue was reproduced. Disturbances in certain mechanisms of intra-tissue regulatory system accompanied by formation of tumor growth foci were simulated experimentally.

(PDF 0-2 workdays service)

Order PDF Full Text


Click here to order any other PDF Full Text

Accession: 006418781

PDF Full Text: Submit

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Other references

Sassoon, H.F.; Watson, J.R.; Bullard, W.J.; Johnson, B.C.; Watson, J., 1967: Preparation of aortic tissue for measurement of enzyme activity. Standardized methods are described for the preparation of intracellular fluid from human, hog, and rat aortas. Tests on hog aortas, which were physically the toughest, suggested that extraction was about 93% complete. Comparison of enzyme and prot...

Speers, R.D., 1996: Confidentiality at risk. Journal 62(7): 563-565

Macphee, C.H.uston; Tew, D.G.aham; Hickey, D.M.ry Bernadette, 2002: Phospholipase A2 inhibitors thereof and use of same in diagnosis and therapy. The enzyme Lp-PLA2 in purified form, an isolated nucleic acid molecule incoding Lp-PLA2, the use of an inhibitor of the enzyme Lp-PLA2 in therapy and a method of screening compounds to identify those compounds which inhibit the enzyme.

Larouche, V.; Capra, M.; Huang, A.; Bartels, U.; Bouffet, E., 2006: Supratentorial primitive neuroectodermal tumors in young children. Journal of Clinical Oncology 24(35): 5609; Author Reply 5609-10

Moon, H-Won.; Whang, D.Hee.; Ko, Y.Jin.; Joo, S.Young.; Yun, Y-Min.; Hur, M.; Kim, J.Q., 2012: Reference interval and determinants of the serum homocysteine level in a Korean population. In this study, we estimated the reference intervals of the serum homocysteine (Hcy) level using two automated immunoassays, and we demonstrated the effects of various factors on the Hcy level in a Korean population. We calculated the gender- and a...

Ripley, B.J.M.; Rahman, M.A.; Isenberg, D.A.; Latchman, D.S., 2005: Elevated expression of the Brn-3a and Brn-3b transcription factors in systemic lupus erythematosus correlates with antibodies to Brn-3 and overexpression of Hsp90. Objective. Important developmental and antiapoptotic roles have been described for the Brn-3 family of transcription factors in mammalian cells. Following a report of pathogenic autoantibody-inducing T cell reactivity to the Brn-3 transcription fa...

MOENCH.A.; SARTORIUS.H., 1954: Clinical studies on testosterone therapy of nephrotic syndrome. Klinische Wochenschrift 32(13-14): 329-330

Harada, Y.; Ra, H.; Yoshimine, A.; Zeze, R.; Ogawa, K.; Wada, T.; Mori, S.I.; Morinaga, Z.; Kanda, N.; Kobayashi, S., 1988: The course of the mandibular canal at the mental foramen region. Part 1. Radiographic survey from the tooth axis. Fukuoka Shika Daigaku Gakkai Zasshi 14(4): 376-381

Johnson, V.A.; Brun-Vézinet, Fçoise.; Clotet, B.; Günthard, H.F.; Kuritzkes, D.R.; Pillay, D.; Schapiro, J.M.; Richman, D.D., 2007: Update of the drug resistance mutations in HIV-1: 2007. Topics in HIV Medicine 15(4): 119-125

Cuesta, A.M.; Sánchez-Martín, D.; Sanz, L.; Bonet, J.; Compte, M.; Kremer, L.; Blanco, F.J.; Oliva, B.; Alvarez-Vallina, L., 2009: In vivo tumor targeting and imaging with engineered trivalent antibody fragments containing collagen-derived sequences. There is an urgent need to develop new and effective agents for cancer targeting. In this work, a multivalent antibody is characterized in vivo in living animals. The antibody, termed "trimerbody", comprises a single-chain antibody (scFv...