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Simulation of tumor growth initiation in constantly renewing cell systems


, : Simulation of tumor growth initiation in constantly renewing cell systems. Voprosy Onkologii (St Petersburg) 30(5): 74-80

A discrete stochastic model simulating a cell renewal system is discussed. The model is based on a functional approach to the present-day concepts on the nature of process of cell proliferation and differentiation as well as mechanisms responsible for integration of these processes. Due to application of specialized programming means of simulation (language GPSS/360) a complete functional pattern of maintenance of cell-population homeostastis in tissue was reproduced. Disturbances in certain mechanisms of intra-tissue regulatory system accompanied by formation of tumor growth foci were simulated experimentally.

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