+ Translate

Simultaneous analysis of carbamazepine and carbamazepine 10 11 epoxide by gas chromatography chemical ionization mass spectrometry stable isotope methodology

, : Simultaneous analysis of carbamazepine and carbamazepine 10 11 epoxide by gas chromatography chemical ionization mass spectrometry stable isotope methodology. Analytical Letters 11(2): 119-134

Carbamazepine 5 and carbamazepine-10,11-epoxide 6, containing 90% 13C at position 10 were synthesized and utilized as internal standards for the quantitative analysis of the parent drug and its metabolite from the plasma of treated rhesus monkeys. A typical analysis involved the addition of a 50 .mu.l methanolic stock solution containing 500 ng of 3 and 100 ng of 4 to 0.5 ml of plasma. The plasma was extracted and analyzed by GC/CI/MS. The precision of the assay, based on 16-18 standard curves obtained over a period of 2 mo. was: 4% and 11% for carbamazepine at concentrations of 2 .mu.g/ml and 0.2 .mu.g/ml, respectively, and 7% and 11% for carbamazepine-10,11-epoxide at concentrations of 0. 2 .mu.g/ml and 0. 02 .mu.g/ml, respectively.

(PDF 0-2 workdays service)

Order PDF Full Text


Click here to order any other PDF Full Text

Accession: 006418943

PDF Full Text: Submit

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Other references

Mumghamba, E.G.S.; Pitiphat, W.; Matee, M.I.N.; Simon, E.; Merchant, A.T., 2004: The usefulness of using Ramfjord teeth in predicting periodontal status of a Tanzanian adult population. The only partial mouth index that has been validated against full-mouth examinations in the East African population is the CPITN (Community Periodontal Index of Treatment Needs). Since the Ramfjord index can potentially shorten the examination tim...

Sawyer, M.H., 2016: The Pertussis Problem and a Possible Solution: Will Parents Go Along?. JAMA Pediatrics 170(5): 421-422

Moore, C.M.; Akers, N.L.; Hill, A.D.; Johnson, Z.C.; Minteer, S.D., 2004: Improving the environment for immobilized dehydrogenase enzymes by modifying Nafion with tetraalkylammonium bromides. Recent research in our group has shown that mixture-casting Nafion with quaternary ammonium bromides can increase the electrochemical flux of redox couples through the membrane and allow for larger redox species to diffuse to the electrode surface...

Reyst, A. T., 1953: Voedsel voor jonge gladde slangen. Lacerta 11, 7: 47-48

Sukhikh, O.A.; Motina, L.I.; Shishkova, E.A.; Yugova, L.V.; Bravova, G.B., 2007: Production of a galactozyme preparation for correction of lactase deficiency. A preparation, Galactozyme, was obtained from a commercial preparation (Lactocanescin) using additional purification procedures (ultrafiltration, microfiltration and precipitation with ethanol). The standardized galactosidase activity in the sugge...

Kim, S.Jin.; Gobi, K.Vengatajalabathy.; Iwasaka, H.; Tanaka, H.; Miura, N., 2007: Novel miniature SPR immunosensor equipped with all-in-one multi-microchannel sensor chip for detecting low-molecular-weight analytes. A simple and versatile miniaturized surface plasmon resonance (SPR) immunosensor enabling parallel analysis of multiple analytes or multiple samples of an analyte has been investigated for detection of a low-molecular-weight (lmw) toxin, 2,4-dichl...

Hopkins, M.E.; Nitecki, R.; Bucci, D.J., 2012: Physical exercise during adolescence versus adulthood: differential effects on object recognition memory and brain-derived neurotrophic factor levels. It is well established that physical exercise can enhance hippocampal-dependent forms of learning and memory in laboratory animals, commensurate with increases in hippocampal neural plasticity (brain-derived neurotrophic factor [BDNF] mRNA/protein...

Mueldner Alfred, 1934: Ueber untersilurische Geschiebe der Stufe D (sub 1). Pebbles found in Germany, derived from Lower Silurian beds of formation D (sub 1) .

Lerner A.A.; Solomenko A.V., 1990: Alloplasty of subtotal defect of the first metacarpal bone during primary surgical treatment of a wound. Zdravookhranenie Belorussii (9): 48

Cui, Z.; Bauman, A.; Dibley, M.J., 2011: Temporal trends and correlates of passive commuting to and from school in children from 9 provinces in China. Examine trends and correlates of passive (inactive) commuting to school among Chinese children aged 6 18years in nine provinces. The trends analysis used school commuting data from the China Health and Nutrition Surveys in 1997 (n=2454), 2 (n=197...