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Simultaneous analysis of carbamazepine and carbamazepine 10 11 epoxide by gas chromatography chemical ionization mass spectrometry stable isotope methodology

Simultaneous analysis of carbamazepine and carbamazepine 10 11 epoxide by gas chromatography chemical ionization mass spectrometry stable isotope methodology

Analytical Letters 11(2): 119-134

Carbamazepine 5 and carbamazepine-10,11-epoxide 6, containing 90% 13C at position 10 were synthesized and utilized as internal standards for the quantitative analysis of the parent drug and its metabolite from the plasma of treated rhesus monkeys. A typical analysis involved the addition of a 50 .mu.l methanolic stock solution containing 500 ng of 3 and 100 ng of 4 to 0.5 ml of plasma. The plasma was extracted and analyzed by GC/CI/MS. The precision of the assay, based on 16-18 standard curves obtained over a period of 2 mo. was: 4% and 11% for carbamazepine at concentrations of 2 .mu.g/ml and 0.2 .mu.g/ml, respectively, and 7% and 11% for carbamazepine-10,11-epoxide at concentrations of 0. 2 .mu.g/ml and 0. 02 .mu.g/ml, respectively.

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