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Simultaneous effects of dietary molybdenum and copper on key enzymes of rat liver. A histochemical study

Simultaneous effects of dietary molybdenum and copper on key enzymes of rat liver. A histochemical study

Industrial Health 20(3): 219-226

Mo and Cu when administered to animals accumulate predominantly in liver, causing identifiable toxic effects on enzyme systems. Since Mo and Cu are known as antagonists, effects of their combined treatment were described in this investigation taking enzymes of key importance, i.e., alkaline phosphatase, acid phosphatase, glucose-6-phosphatase, 5-nucleotidase, esterases and cholinesterase in the liver of the albino rat Rattus rattus. Comparison of controls with the combined effects revealed an increase in the activity of enzymes studied; however, some remarkable differences in their topography were observed. Antagonistic behavior of Mo and Cu at the enzymological level was explained on the basis that Cu becomes unavailable through interaction with molybdate to form either cupric molybdate or copper thiomolybdate which is ultimately excreted. The results were further interpreted in terms of combined effects of Mo and Cu on cellular organelles, levels of enzyme protein and microenvironment of the hepatic parenchyma.

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Accession: 006419740

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PMID: 7174376

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