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Simultaneous occurrence of transitional cell carcinoma squamous cell carcinoma and adeno carcinoma of the bladder after 15 years of cyclo phosphamide ingestion



Simultaneous occurrence of transitional cell carcinoma squamous cell carcinoma and adeno carcinoma of the bladder after 15 years of cyclo phosphamide ingestion



Journal of Urology 125(3): 424-426



A patient is reported who had a urothelial tumor with tri-differentiation into transitional, squamous and adenocarcinoma after ingestion of 285 cyclophosphamide during a 15 yr period. The possibility is again raised that the use of high doses of this drug over long periods may be associated with an increased incidence of carcinoma of the bladder. Frequent cystoscopic examinations may be warranted in patients who have received large cumulative amounts of the drug.

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Accession: 006420379

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