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Size heterogeneity of prolactin secreted from and stored in the rat anterior pituitary gland in vitro

Size heterogeneity of prolactin secreted from and stored in the rat anterior pituitary gland in vitro

Bioscience Reports 4(2): 129-138

The size heterogeneity of rat pituitary prolactin was investigated using anterior pituitary glands from female rats incubated in vitro and gel filtration on Sephadex G-100. Monomeric prolactin was preferentially secreted compared with dimeric and trimeric material. When glands were incubated with dopamine, prolactin secretion was inhibited and the relative proportion of dimer in the gland (but not the medium) was decreased. Morphine sulfate reversed the effect of dopamine on prolactin secretion and on the proportion of prolactin in the gland that was in the dimeric form. Apparently, monomeric prolactin is more readily secreted than dimer, and dopamine decreased the production or stability of the dimer.

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Accession: 006424702

Download citation: RISBibTeXText

PMID: 6713084

DOI: 10.1007/bf01120309

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