Soluble and nuclear oestrogen receptor status in human breast cancer in relation to prognosis
Leake, R.E.; Laing, L.; Mcardle, C.; Smith, D.C.
British Journal of Cancer 43(1): 67-71
The relationship between estrogen receptor (RE) content of primary breast cancer and subsequent prognosis was examined with regard to nodal status. Within a particular nodal group, patients with tumors containing fully functional RE experienced a longer disease-free interval than those with RE- disease. An earlier observation that RE- primary disease gave rise to distant metastases as 1st site of recurrence more frequently than did RE+ disease was not sustained. Patients with RE+ primary disease had a much reduced chance of dying from cancer within a 3 yr period.