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Specificity of cell mediated cyto toxicity 2. cyto toxic lymphocytes after allogeneic sensitization in vitro in h 2 system



Specificity of cell mediated cyto toxicity 2. cyto toxic lymphocytes after allogeneic sensitization in vitro in h 2 system



Allergie und Immunologie (Leipzig) 29(2): 100-107



Allogeneic i.p. immunization in vivo leads to induction of cytotoxic lymphocytes [in mice]. The cytotoxic reaction of these lymphocytes is specific in vitro against thymocytes as target cells and depends on identical private determinants of stimulator and target cell haplotype. Cross reactions are not observed in this model with H-2 incompatible haplotypes as target cells; no autoreactivity was found. If effector cells are used after stimulation in a mixed lymphocyte culture and mitogen stimulated spleen cells as target cells, cross reactions as well as autoreactivity were observed. Conditions of the trial determine the results. In vivo and in vitro induced effector cells destroy thymocytes as well as spleen cell blasts. The type of target cell does not influence the specificity of the cytotoxic reaction. Only in vivo induced effector cells react specifically.

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Accession: 006458522

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