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Specificity of the extraction fluorescence assay for serum or plasma quinidine


, : Specificity of the extraction fluorescence assay for serum or plasma quinidine. Journal of Clinical Pharmacology 21(8-9): 333-336

Randomly selected serum samples [26] from patients receiving long-term antiarrhythmic therapy with oral quinidine preparation were assayed by both a modification of the extraction fluorescence technique and high-pressure liquid chromatography, with highly comparable results (r = 0.98). A literature review on comparing the extraction fluorescence technique's results with other methods indicates a high degree of agreement. Because variations from study to study exist, investigators using the extraction fluorescence technique should assess the specificity of the method in their own laboratory.

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Related references

Greenblatt, D.J.; Woo, E., 1981: The specificity of the extraction fluorescence assay for serum or plasma quinidine. A series of 26 randomly selected serum samples from patients receiving long-term antiarrhythmic therapy with oral quinidine preparation were assayed by both a modification of the extraction fluorescence technique and high-pressure liquid chromatog...

Kurakane E.; Amada A., 1981: Determination of quinidine in equine plasma an extraction fluorescence method. To investigate the pharmacokinetics of quinidine in the horse, an extraction fluorescence method was developed for determination of quinidine in equine plasma. Plasma quinidine concentrations were determined by 2 fluorescence methods, which were t...

Smith, G.H.; Levy, R.H., 1982: Serum quinidine determination: comparison of mass-spectrometric and extraction-fluorescence methods. A comparison of two analytical methods of quinidine plasma determination--the modified extraction fluorometric method and the mass spectrometric method--was made. Plasma supplies collected at steady state from normal human volunteers participating...

Moulin M.A.; Camsonne R.; Bigot M C.; Debruyne D., 1981: Very rapid reversed phase high performance liquid chromatographic assay for serum quinidine without prior extraction step a micro scale procedure. IRCS (International Research Communications System) Medical Science Library Compendium 9(5): 421

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