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Specificity of the extraction fluorescence assay for serum or plasma quinidine

, : Specificity of the extraction fluorescence assay for serum or plasma quinidine. Journal of Clinical Pharmacology 21(8-9): 333-336

Randomly selected serum samples [26] from patients receiving long-term antiarrhythmic therapy with oral quinidine preparation were assayed by both a modification of the extraction fluorescence technique and high-pressure liquid chromatography, with highly comparable results (r = 0.98). A literature review on comparing the extraction fluorescence technique's results with other methods indicates a high degree of agreement. Because variations from study to study exist, investigators using the extraction fluorescence technique should assess the specificity of the method in their own laboratory.

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