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Specificity of the inhibitory effect of a grand multi para serum on mixed leukocyte culture reactions and on responses to phyto hem agglutinin pokeweed mitogen and purified protein derivative

, : Specificity of the inhibitory effect of a grand multi para serum on mixed leukocyte culture reactions and on responses to phyto hem agglutinin pokeweed mitogen and purified protein derivative. Acta Pathologica et Microbiologica Scandinavica Section C Immunology 85(6): 424-434

An MLC [mixed leukocyte culture] reaction inhibiting serum from a grand-multiparous woman (16 successful pregnancies) is described. The serum producer had the HLA antigens A3;Bw35/Aw19;B18;Dw2 and her husband the antigens A28;Bw35/Aw19;B18;Dw2, and they responded to each other in 1-way MLC. The serum had the following characteristics: it inhibited many but not all donors as stimulators in MLC; it usually inhibited these same donors as responders in MLC, but clearly to a lesser degree and with a much lower titer; the inhibition of the stiumlating function followed HLA haplotypes in families, and seemed to have HLA-D associated specificity, inhibiting HLA-Dw3 and Dw6 homozygous but not HLA-Dw2 or Dw4 homozygous cells as stimulators; it inhibited more strongly the PWM [pokeweed mitogen] and PPD [purified protein derivative] responses than the MLC responses of relevant cells; the Ig[immunoglobulin]G fraction of the serum had characteristics similar to the non-fractionated serum; the inhibitory effect on MLC reactions and PWM and PPD responses was not absorbable by specific red blood cells or platelets, but could be removed or diminished by specific lymphocytes; the serum was not cytotoxic in the complement-dependent test against non-fractionated mononuclear cells or enriched B[bone marrow derived]-lymphocytes. The findings and the possible biological and clinical significance of human Ia[immune response associated]-like antibodies are discussed.

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