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Specificity of the interaction between estrogen and cytoplasmic receptors in cercopithecus griseus uterus and oviduct

, : Specificity of the interaction between estrogen and cytoplasmic receptors in cercopithecus griseus uterus and oviduct. Voprosy Meditsinskoi Khimii 28(4): 56-58

The specificity of interaction in C. griseus of uterine and oviduct cytosol receptor systems iwth 14 estrogenic substances was characterized. The activity of steroid-receptor interaction was mainly due to the presence of hydroxyl groups in C3- and C17b-positions. The nearest environment of these functional groups in molecules also affected the affinity of steroids to the systems investigated. Analysis of the cytosol estrogen-receptor system specificity from C. griseus, guinea pig, human uterus and oviduct showed the general pattern of the estrogen binding to the above-mentioned systems. Similarity was also noted between these C. griseus and human estrogen-receptor systems.

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