+ Site Statistics
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Specificity of the suppressive action of gluco corticoids on the proliferation of monocyte macrophages in the colony stimulating factor stimulated cultures of mouse bone marrow

, : Specificity of the suppressive action of gluco corticoids on the proliferation of monocyte macrophages in the colony stimulating factor stimulated cultures of mouse bone marrow. Experimental Hematology (Charlottesville) 11(3): 178-186

Addition of cortisol and its analogs to soft-agar culture of bone marrow cells markedly decreased the number of monocyte colonies in the presence of colony-stimulating factor [CSF]. Steroids of other categories and cortisol metabolites were much less inhibitory than cortisol, and the shape of dose-response curve apparently differed between cortisol and other steroids. The action of cortisol was not influenced by excess progesterone or testosterone. Addition of cortisol succinate in liquid cultures of CSF-stimulated cells caused a gradual decrease of cellular uptake of [3H]thymidine. The steroid suppressed CSF-independent [3H]thymidine uptake, but the time course of suppression obviously differed from that of CSF-dependent uptake. On day 7 of incubation, the steroid-treated cultures contained a smaller number of cells but higher activities of lysosomal enzymes than the control cultures. The glucocorticoids evidently inhibit proliferation of the cells of monocyte/macrophage lineage.

(PDF 0-2 workdays service)

Order PDF Full Text


Click here to order any other PDF Full Text

Accession: 006459131

PDF Full Text: Submit

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Other references

Sudthongkong, C., 2007: Isolation and identification of viral pathogens in diseased giant freshwater prawn (Macrobrachium rosenbergii) larvae in Thailand. The isolation and identification of viral pathogens in diseased giant freshwater prawn Macrobrachium rosenbergii in Thailand during 2004 to 2005 were performed. Juvenile prawn was the most susceptible stage and mortality reached 80% of the stocks...

Goebel, A.; Epprecht, M., 1995: Women and employment in sub-Saharan Africa: testing the World Bank and WID models with a Lesotho case study. This paper offers an empirical study of a weaving enterprise (Mosebetsi) in Lesotho to test the theory and prescription of the liberal women in development (WID) approach within the World Bank model of development. The business selected provided a...

Medon P.J.; Ferguson P.W.; Watson C.F., 1984: Effects of eleutherococcus senticosus extracts on hexo barbital metabolism in vivo and in vitro. Eleutherococcus senticosus (Siberian ginseng) is widely exported from China as a health food. Pharmacologically it has been classified as an adaptogen and enzyme induction has been proposed as its mechanism of action. To evaluate this hypothesis E...

Ridley, M. F., 1957: The natural habitat of Cladosporium carrionii, a cause of chromoblastomycosis in Man. Evidence regarded as reasonably complete is presented from comparative sero-logical studies and inoculation experiments on 3 volunteers that the organisms isolated from fence posts in Queensland were strains of C.

Anonymous, 2011: Modulation of lipopolysaccharide receptor expression by lactate dehydrogenase-elevating virus. Lactate dehydrogenase-elevating virus (LDV) exacerbates mouse susceptibility to endotoxin shock through enhanced tumour necrosis factor (TNF) production by macrophages exposed to lipopolysaccharide (LPS). However, the in vivo enhancement of TNF pr...

Heiny D.K.; Gilchrist D.G., 1991: Synthesis and biological activity of stemtoxin by stemphylium botryosum and related fungi. Ulocladium sp., Alternaria alternata f. sp. lycopersici, Stemphylium vesicarium and several isolates of Stemphylium botryosum were tested for their ability to produce polypeptides (Mr = 26,900; 19,500; triplet at 15,500) similar to those associate...

Anonymous, 2012: Effects of inhaled nitric oxide on haemostasis in healthy adults treated with heparin a randomized, controlled, blinded crossover study. Effects of nitric oxide (NO) on hemostasis have been studied in various investigational settings, but data regarding inhaled NO on bleeding and platelet function are conflicting. It is not known if inhaled NO has an effect when administered with d...

De-Wet, Jmj, 1983: Biotechnology and the future of agriculture. Illinois research 25(4): 3-6

Mangin, Jean Francois; Frouin, Vincent; Bloch, Isabelle; Bendriem, Benard; Lopez Krahe, Jaime, 1994: Fast nonsupervised 3D registration of PET and MR images of the brain. We propose a fully nonsupervised methodology dedicated to the fast registration of positron emission tomography (PET) and magnetic resonance images of the brain. First, discrete representations of the surfaces of interest (head or brain surface) a...

Knight, WJ., 1987: Leafhoppers of the grass-feeding genus Balclutha (Homoptera, Cicadellidae) in the Pacific region. The Pacific fauna of the grass-feeding cicadellid genus Balclutha is reviewed, and descriptions and a key are given to the 30 valid species, including 14 new species. Twenty-eight new synonymies are established and 24 lectotypes designated. The ec...