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Specificity of the suppressive action of gluco corticoids on the proliferation of monocyte macrophages in the colony stimulating factor stimulated cultures of mouse bone marrow


, : Specificity of the suppressive action of gluco corticoids on the proliferation of monocyte macrophages in the colony stimulating factor stimulated cultures of mouse bone marrow. Experimental Hematology (Charlottesville) 11(3): 178-186

Addition of cortisol and its analogs to soft-agar culture of bone marrow cells markedly decreased the number of monocyte colonies in the presence of colony-stimulating factor [CSF]. Steroids of other categories and cortisol metabolites were much less inhibitory than cortisol, and the shape of dose-response curve apparently differed between cortisol and other steroids. The action of cortisol was not influenced by excess progesterone or testosterone. Addition of cortisol succinate in liquid cultures of CSF-stimulated cells caused a gradual decrease of cellular uptake of [3H]thymidine. The steroid suppressed CSF-independent [3H]thymidine uptake, but the time course of suppression obviously differed from that of CSF-dependent uptake. On day 7 of incubation, the steroid-treated cultures contained a smaller number of cells but higher activities of lysosomal enzymes than the control cultures. The glucocorticoids evidently inhibit proliferation of the cells of monocyte/macrophage lineage.

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Other references

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Goebel, A.; Epprecht, M., 1995: Women and employment in sub-Saharan Africa: testing the World Bank and WID models with a Lesotho case study. This paper offers an empirical study of a weaving enterprise (Mosebetsi) in Lesotho to test the theory and prescription of the liberal women in development (WID) approach within the World Bank model of development. The business selected provided a...

Medon P.J.; Ferguson P.W.; Watson C.F., 1984: Effects of eleutherococcus senticosus extracts on hexo barbital metabolism in vivo and in vitro. Eleutherococcus senticosus (Siberian ginseng) is widely exported from China as a health food. Pharmacologically it has been classified as an adaptogen and enzyme induction has been proposed as its mechanism of action. To evaluate this hypothesis E...

Ridley, M. F., 1957: The natural habitat of Cladosporium carrionii, a cause of chromoblastomycosis in Man. Evidence regarded as reasonably complete is presented from comparative sero-logical studies and inoculation experiments on 3 volunteers that the organisms isolated from fence posts in Queensland were strains of C.

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Anonymous, 2012: Effects of inhaled nitric oxide on haemostasis in healthy adults treated with heparin a randomized, controlled, blinded crossover study. Effects of nitric oxide (NO) on hemostasis have been studied in various investigational settings, but data regarding inhaled NO on bleeding and platelet function are conflicting. It is not known if inhaled NO has an effect when administered with d...

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