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Specificity of the tests proposed for the detection of small airway disease


, : Specificity of the tests proposed for the detection of small airway disease. Bulletin Europeen de Physiopathologie Respiratoire 12(3): 477-486

Tests proposed for the detection of disease of the small airways cannot be interpreted unless routine spirographic tests, bronchial resistance and the pulmonary elasticity curve are normal. The reduction in pulmonary compliance as a function of frequency may reflect an obstruction of the central bronchi. Similarly, forced expiratory outputs of approximately 50% of vital capacity are more influenced by a central obstruction than by a peripheral obstruction. Maximal outputs measured at values near the residual volume, the closure and iso-output volumes, can all be modified by an initial change in the static-volume pressure curve, such as in the loss of parenchymal elasticity of the lung.

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Related references

van de Woestijne, K.P., 1976: Specificity of tests for detection of small airway disease. Bulletin Europeen de Physiopathologie Respiratoire 12(3): 477-486

Roberts C.M.; Rawbone R.G.; Adams L.; Seed W.A., 1990: Sensitivity and specificity of small airway tests in subjects with normal conventional lung function tests. Clinical Science (London) 78(4): 29P

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Harrison, G.N.; Moor, G.R.; Mohler, J.L.; Speir, W.A., 1978: Small airway disease: comparison of tests in young smokers versus nonsmokers. A number of new tests for detection of small airway disease have been developed in the past several years. It is hoped that these will prove valuable as screening tests to detect those at risk of developing obstructive airway disease. We obtained...

Boeck, L.; Gensmer, A.; Nyilas, S.; Stieltjes, B.; Re, T.J.; Tamm, M.; Latzin, P.; Stolz, D., 2016: Single-Breath Washout Tests to Assess Small Airway Disease in COPD. Current functional assessments do not allow a reliable assessment of small airways, which are a major site of disease in COPD. Single-breath washout (SBW) tests are feasible and reproducible methods for evaluating small airway disease. Their relev...

Satake, T.; Ryuge, K.; Takagi, K.; Hara, M., 1976: Large airway and small airway--studies on early detection of airway obstruction. Kokyu to Junkan. Respiration & Circulation 24(7): 589-598