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Specificity of translational regulation by 2 dna binding proteins

, : Specificity of translational regulation by 2 dna binding proteins. Journal of Molecular Biology 173(2): 211-226

The gene V protein of the filamentous phages fl, fd and M13, and the gene 32 protein of phage T4 share the property of binding strongly and co-operatively to single-stranded nucleic acids, especially DNA. Both are capable of repressing the translation of specific mRNA (gene 32 protein its own and gene V protein that of the filamentous phage gene II), in vivo and in vitro. If the mechanism of repression by either of these proteins were based solely on its ability to bind single strands co-operatively, then the other would be expected to mimic or interfere with its effect in vitro. No such mimicry or interference was found, even at protein concentrations high enough to have substantial non-specific effect on translation. This suggests that the sites of repression on the mRNA must offer something other than simple unstructuredness for binding and repression to occur.

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