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Specificity repertoire of lymphocytes from multiple myeloma patients 1. high frequency of b cells specific for idiotypic and fab' 2 region determinants on immunoglobulin

, : Specificity repertoire of lymphocytes from multiple myeloma patients 1. high frequency of b cells specific for idiotypic and fab' 2 region determinants on immunoglobulin. Journal of Clinical Immunology 5(4): 275-284

The specificity repertoire of B lymphocytes from 14 multiple myeloma patients was studied using the technique of Epstein-Barr virus (EBV) transformation of peripheral blood lymphocytes (PBL) coupled with clonal analysis by limiting dilution. It was found that up to 100% of the B cells from myeloma patients undergoing EBV transformation secrete IgM specific for determinants on the F(ab')2 region of autologous and/or heterologous monoclonal Ig. In normal individuals 0.02-0.73% of the transformed B cells secrete IgM specific for F(ab')2 determinants. Two patients with monoclonal gammopathy of undetermined significance had only a weak reactivity to F(ab')2 fragments. The number of anti-F(ab')2 B cells was up to 145-fold greater in patients than in normal donors. The majority of antibodies from patient clones recognized determinants shared among 3-12 different F(ab')2 fragments, whereas those originating from normal donor B cells saw determinants expressed on only 1 or 2 of the panel of test F(ab')2 fragments. There was a preference for autologous M components and a high proportion of antiidiotypic reactivity in 5 of 8 patients so analyzed. These findings may indicate the existence of an anti-F(ab')2 immunoregulatory network mediating patient immunodeficiency, thereby creating an abnormality that may enable the progression of multiple myeloma.

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