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Specificity studies on the oligo saccharide neuraminidase ec 3.2.1.18 of human fibroblasts


Biochemical Journal 218(2): 625-628
Specificity studies on the oligo saccharide neuraminidase ec 3.2.1.18 of human fibroblasts
Competition and thermal inactivation experiments with different potential natural substrates indicated that in homogenates of human fibroblasts one single enzyme is acting on both (.alpha.2-3) and (.alpha.2-6) sialosyl linkages of oligosaccharides and glycoproteins, but not of the ganglioside GM3. N-Acetylneuraminic and 2-deoxy-2,3-dehydro-N-acetylneuraminic acids are competitive inhibitors, whereas chondroitin 4-sulfate and the drug Suramin are potent inhibitors of undefined type.


Accession: 006459212



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