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Spectinomycin chemistry part 3 9 epi 4r di hydro spectinomycin and 9 epi spectinomycin

, : Spectinomycin chemistry part 3 9 epi 4r di hydro spectinomycin and 9 epi spectinomycin. Journal of Antibiotics (Tokyo) 31(10): 985-990

The preparation of 9-epi-4(R)-dihydrospectinomycin and of 9-epi-spectinomycin is described.

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Related references

Foley, L.; Weigele, M., 1978: Spectinomycin chemistry part 1 characterization of a 5a 9a epi 4r di hydro spectinomycin derivative. The identification of a diastereomeric derivative of 4(R)-dihydrospectinomycin, having the reversed absolute stereochemistry in the cyclitol ring, is reported. The chemical transformations providing the unequivocal proof of a structure for this co...

Foley, L.; Lin, J.T.S.; Weigele, M., 1978: Spectinomycin chemistry part 2 9 deoxy 4r di hydro spectinomycin and 9 deoxy spectinomycin. A [synthetic] route to 9-deoxyspectinomycin and 9-deoxy-4(R)-dihydrospectinomycin is described.

Rosenbrook, W.J. ; Carney, R.E.; Egan, R.S.; Stanaszek, R.S.; Cirovic, M.; Nishinaga, T.; Mochida, K.; Mori, Y., 1978: Spectinomycin modification part 4 7 deoxy 4r di hydro spectinomycin. 7-Deoxy-4(R)-dihydrospectinomycin was prepared and its structure firmly established by PMR and high resolution mass spectrometry. This spectinomycin analog is devoid of antibiotic activity.

Rosenbrook W.Jr; Carney R.E., 1975: Spectinomycin modification part 1 7 epi 9 deoxy 4 r di hydro spectinomycin. Journal of Antibiotics (Tokyo) 28(12): 953-959

Foley, L.; Lin, J.T.; Weigele, M., 1978: Spectinomycin chemistry. III.9-EPI-4(R)-dihydrospectinomycin and 9-epi-spectinomycin. Journal of Antibiotics 31(10): 985-990

Rosenbrook W.Jr; Carney R.E.; Egan R.S.; Stanaszek R.S.; Cirovic M.; Nishinaga T.; Mochida K.; Mori Y., 1975: Spectinomycin modification part 2 7 epi spectinomycin. Journal of Antibiotics (Tokyo) 28(12): 960-964

Boslego, J.W.; Tramont, E.C.; Takafuji, E.T.; Diniega, B.M.; Mitchell, B.S.; Small, J.W.; Khan, W.N.; Stein, D.C., 1987: Effect of spectinomycin use on the prevalence of spectinomycin-resistant and of penicillinase-producing Neisseria gonorrhoeae. Because of the high prevalence of penicillinase-producing Neisseria gonorrhoeae in the Republic of Korea, spectinomycin has been used there in the primary treatment of gonococcal infections in U.S. military personnel since 1981, but there have bee...

Yu, G.C.eng; Wang, J.H.a; Shao,, 1994: Selection of spectinomycin resistant, high yielding spectinomycin producing strains. The spore suspension of the spectinomycin producing mutant No. 47-4 after treatment by combination of lithium chloride and ultraviolet light, was selected on the gradient plates containing 5000 mu-g/ml spectinomycin in Gause No. 1 medium. It was p...

Hanley, J.E.; Davis, R.B.; Sunka, E.M., 1968: An evaluation and comparison of spectinomycin and spectinomycin-erythromycin combinations for infectious coryza. A comparison and evaluation was made of Spectinomycin and of Spectinomycin-erthromycin combinations in the treatment of infectious coryza in chickens under simulated field conditions. The drugs appeared to be of value in the treatment, with Specti...

Thomas, R.C.; Fritzen, E.L., 1985: Spectinomycin modification 3. spectinomycin analogs with carbon 3' branched chain sugars. A variety of C-3'-branched chain analogs of spectinomycin was synthesized via the intermediacy of spectinomycin derived diazoketones. In vitro antibacterial assay of these compounds underscored the importance of H bonding functional groups in...