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Spectinomycin resistant gonococci

, : Spectinomycin resistant gonococci. British Medical Journal 287(6408): 1827-1829

A study was conducted examining the properties of 10 clinical isolates of spectinomycin resistant gonococci from patients attending clinics at St. Mary's and St. Thomas's Hospitals, London [England, UK]. All of the isolates produced .beta.-lactamase, and contained plasmids of 2.6, 4.4 and 24.5 megadaltons and required proline for growth. None produced aminoglycoside modifying enzymes. Resistance to spectinomycin was transferred from some of the isolates by transformation but at a much lower frequency than resistance to streptomycin. The isolates from St. Mary's Hospital were detected after therapy with spectinomycin; those from St. Thomas's Hospital were not. Four recent non-.beta.-lactamase producing gonococci isolated at St. Mary's Hospital and 2 isolated at St. Thomas's Hospital also were not related to use of spectinomycin.

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Accession: 006459331

PMID: 6231077

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