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Spectral analysis of mouse electro encephalogram after the administration of n n di methyl tryptamine


, : Spectral analysis of mouse electro encephalogram after the administration of n n di methyl tryptamine. Biological Psychiatry 12(6): 757-770

Mice were implanted with permanent cortical electrodes and the EEG was recorded during the sleep-wake cycle and after administration of N,N-dimethyltryptamine (DMT) [ahallucinogen]. Based on spectral analysis the EEG was classified into 3 categories: awake, slow-wave sleep (SWS) and rapid eye movement sleep (REM). The dominant frequencies were located below 2 Hz in the case of SWS and between 6 and 9 Hz for REM. When DMT was administered (i.p.) at 20 or 40 mg/kg, a dose-dependent hypersynchrony at 2.5-4.5 Hz was always observed lasting for up to 60 min and was occasionally observed in the same range during awake. In this range DMT induced a different but unique frequency for each animal which was reproducible by repeated administrations of DMT.

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