EurekaMag.com logo
+ Translate

Spectral analysis of mouse electro encephalogram after the administration of n n di methyl tryptamine


, : Spectral analysis of mouse electro encephalogram after the administration of n n di methyl tryptamine. Biological Psychiatry 12(6): 757-770

Mice were implanted with permanent cortical electrodes and the EEG was recorded during the sleep-wake cycle and after administration of N,N-dimethyltryptamine (DMT) [ahallucinogen]. Based on spectral analysis the EEG was classified into 3 categories: awake, slow-wave sleep (SWS) and rapid eye movement sleep (REM). The dominant frequencies were located below 2 Hz in the case of SWS and between 6 and 9 Hz for REM. When DMT was administered (i.p.) at 20 or 40 mg/kg, a dose-dependent hypersynchrony at 2.5-4.5 Hz was always observed lasting for up to 60 min and was occasionally observed in the same range during awake. In this range DMT induced a different but unique frequency for each animal which was reproducible by repeated administrations of DMT.

(PDF 0-2 workdays service)

Accession: 006459430

Submit PDF Full Text: Here


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Related references

Wyler, A.R.; Lockard, J.S.; Ducharme, L.L.; Perkins, M.G., 1977: Electro encephalogram operant conditioning in a monkey model part 2 electro encephalogram spectral analysis. EEG power spectral analysis was studied from 14 (alumina-gel) chronically epileptic, undrugged monkeys [Macaca mulatta] during an EEG operant conditioning experiment. The composite profile of the average epileptic monkey showed the majority of pow...

Spehr, W.; Sartorius, H.; Berglund, K.; Hjorth, B.; Kablitz, C.; Plog, U.; Wiedemann, P.H.; Zapf, K., 1977: Electro encephalography and hemo dialysis a structural survey of electro encephalographic spectral analysis hjorths electro encephalogram descriptors blood variables and psychological data. Computerized EEG was performed in 20 patients with renal failure before and after hemodialysis (HD), applying spectral analysis and Hjorth's EEG descriptors in EEG quantification, correlation and factor analysis as statistical procedures to a...

O'donnell R.D.; Berkhout J.; Rapp J.; Walter D.O., 1972: Spectral and coherence analysis of simultaneous electro encephalogram and electro myogram during activity. Federation Proceedings 31(2): 404

Zschokke S.T.; Rohr W.; Janzen R.W.C.; Neunzig H.P., 1983: Electro encephalogram electro myogram and continuous spectral analysis in neurological intensive monitoring. Electroencephalography & Clinical Neurophysiology 56(3): S210

Strahilevitz M.; Narasimhachari N.; Fujimori M.; Himwich H.E., 1971: Blocking of 5 methoxy n dimethyl tryptamine induced electro encephalogram alerting in the rabbit by previous administration of anti serum to this compound. Biological Psychiatry 3(3): 227-236

Matthis P.; Scheffner D.; Benninger C., 1981: Spectral analysis of the electro encephalogram comparison of various spectral parameters. One of the main problems in spectral analysis of the EEG consists of finding relevant parameters which are capable of summarizing all information included in the power spectrum. Mathematical properties and the clinical applicability of 4 sets of p...

Moore R.H.; Demetriou S.K.; Domino E.F., 1975: Effects of iproniazid chlorpromazine and methiothepin on di methyl tryptamine induced changes in body temperature pupillary dilatation blood pressure and electro encephalogram in the rabbit. Archives Internationales de Pharmacodynamie et de Therapie 213(1): 64-72

Steinfels G.F.; Young G.A.; Khazan N., 1978: Morphine and methadone self administration in dependent rats associated electro encephalogram spectral changes. Federation Proceedings 37(3): 310

Gundel, A.; Baier, W.; Doose, H.; Hoovey, Z., 1981: Spectral analysis of electro encephalogram in the late course of primary generalized myo clonic astatic epilepsy 1. electro encephalographic and clinical data. The EEG of 38 patients suffering from primary generalized myoclonic astatic epilepsy since early childhood were studied in late stages of the disease. Spectral analysis shows that parietal 4-7 cps rhythms (theta rhythms) which are typical of the E...

Etevenon P.; Kitten G.; D.B.rbeyrac J.; Goldberg P., 1970: Spectral analysis of rats electro encephalogram a program of mean power density spectrum with new computed spectral parameters and its applications in psycho pharmacology. Journal de Pharmacologie (Paris) 1(3): 383-394