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Spectral and correlation characteristics of the human electro encephalogram under the effect of sub narcotic concentrations of methoxyflurane and nitrous oxide

, : Spectral and correlation characteristics of the human electro encephalogram under the effect of sub narcotic concentrations of methoxyflurane and nitrous oxide. Vestnik Akademii Meditsinskikh Nauk SSSR (1): 77-80

The study of spectral and correlative characteristics of EEG with subnarcotic concentrations of methoxyflurane and N2O singly and in combined inhalation was carried out on 17 healthy volunteers. Changes in EEG as a result of exposure to 30% N2O only consisted in a decrease in amplitude of .alpha.-rhythm, (averaging 20%) which correlated with the degree of perception disturbances. Cross and autocorrelation charcteristics were statistically unchanged. Inhalation of 0.1% methoxyflurane produced no statistically reliable changes in the cross and autocorrelation characteristics of EEG. Inhalation of a 30% N2O and 0.1% by volume methoxyflurane mixture during 45 min brought about a moderate inhibition of .alpha.-rhythm (averaging 20%) did not produce reliable correlative changes in EEG and distorted subjective sensations.

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