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Spectral and metabolic characteristics of mitochondrial fractions from rotenone induced tumors



Spectral and metabolic characteristics of mitochondrial fractions from rotenone induced tumors



British Journal of Cancer 36(2): 243-253



Mitochondrial fractions isolated from [rat] tumors induced with the respiratory inhibitor rotenone lack respiratory control, oxidative phosphorylation, are partially or totally insensitive to cyanide and have a near normal content of respiratory carriers. These characteristics are more similar to those of mitochondria from atrophic mammary gland than to those of mitochondria from spontaneous mammary adenomas. The characteristic structural and biochemical mitochondrial alteration of rotenone induced tumors represent a lack of mitochondrial differentiation as the tumor develops from the atrophic mammary gland. Slices of rotenone induced tumors are insensitive to oligomycin and dinitrophenol, indicating that glycolysis would be their sole source of metabolic energy.

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Accession: 006459512

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PMID: 911663



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