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Spectral shift of fluorescein and carboxyfluorescein in the anterior chamber of the rabbit eye following systemic administration

, : Spectral shift of fluorescein and carboxyfluorescein in the anterior chamber of the rabbit eye following systemic administration. Current Eye Research 5(5): 337-341

Systemically administered fluorescein is converted to fluorescein glucuronide. The conjugate is fluorescent and interferes with the measurement of fluorescein in the anterior chamber. Carboxyfluorescein is a hydrophilic derivative of fluorescein. In the rabbit, carboxyfluorescein is not converted as readily to a fluorescent metabolite. Thus, carboxyfluorescein has potential advantages as a quantitative fluorophore for studies of aqueous humor dynamics.

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Accession: 006459917

PMID: 3720340

DOI: 10.3109/02713688609025171

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