EurekaMag.com logo
+ Site Statistics
References:
48,253,228
Abstracts:
22,798,842
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
EurekaMag PDF Full Text Supply ServicePDF Full Text Supply Service
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn
Follow on LinkedInFollow on Tumblr

+ Translate

Spectral study of the photochemistry of di pyrrole models for bilirubin bound to human serum albumin


, : Spectral study of the photochemistry of di pyrrole models for bilirubin bound to human serum albumin. Photochemistry & Photobiology 37(3): 263-270

Dipyrromethenones, which include xanthobilirubinic acid (I), its methyl ester (II) and the endo-vinyl analog of neoxanthobilirubinic acid methyl ester (half bilirubin methyl ester) (III) bind to human serum albumin (HSA) and thereby exhibit greatly increased fluorescence as well as induced circular dichroism in their long wavelength transitions. As determined from fluorescence studies, the tightness of the binding to HSA is inversely related to the inherent solubility of the dipyrromethenone in aqueous buffer. Fast (ps) configurational isomerization (Z .fwdarw. E) is the major pathway for decay of the 1st excited (singlet) states of the HSA-bound dipyrromethenones. A quantum yield of .apprx. 0.4 is associated with the Z .fwdarw. E isomerization. Binding to HSA enhances the lifetimes of the less thermodynamically stable E-isomers. The results of these studies of half bilirubins allow a clear evaluation of the effects of protein binding upon the photophysics and photochemistry of bilirubin. [The orange-yellow bile pigment bilirubin-IX.alpha., is the pigment associated with jaundice.].

(PDF 0-2 workdays service)

Order PDF Full Text

Close
Close

Click here to order any other PDF Full Text


Accession: 006459959

PMID: 6844423

PDF Full Text: Submit


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Other references

La Croix, R.; Tenconi, B.; Di Guilio, A.M.; Mantegazza, P.; Gorio, A., 1989: The gastrointestinal innervation is altered in experimental diabetes. Pharmacological Research 21(1): 129-130

Evens, R.; De Schamphelaere, K.A.C.; De Samber, B.; Silversmit, G.; Schoonjans, T.; Vekemans, B.; Balcaen, L.; Vanhaecke, F.; Szaloki, I.; Rickers, K.; Falkenberg, G.; Vincze, L.; Janssen, C.R., 2012: Waterborne versus dietary zinc accumulation and toxicity in Daphnia magna: a synchrotron radiation based X-ray fluorescence imaging approach. Recent studies have suggested that exposure of the freshwater invertebrate Daphnia magna to dietary Zn may selectively affect reproduction without an associated increase of whole body bioaccumulation of Zn. The aim of the current research was ther...

Richards Horace Gardiner, 1947: Preservation of fossil jellyfish. Geological Society of America Bulletin 58(12, Part 2): 1221

Musaiger A.O.; Gregory W.B., 1990: Change in parasitic infections among school children in bahrain 1980 1986 a preliminary study. Stool specimens were collected from 378 children aged from 6 to 11 years and examined for the detection of intestinal parasitic infections. The prevalence of parasites was also compared with those reported earlier in 1980. The results indicate tha...

Schulze, C.; Schnepf, E.; Mothes, K., 1967: Localization of rubber particles in various types of lactic ducts. The rubber particles are present as simple droplets in the cytoplasm of the mature, jointed latex ducts of Papaver, Hevea, and Taraxacum. They occur in the form of compound particles almost exclusively in the vac-uoles of the unjointed latex ducts...

Roelofs, A.J.; Stewart, C.A.; Sun, S.; Błażewska, K.M.; Kashemirov, B.A.; McKenna, C.E.; Russell, R.Graham.G.; Rogers, M.J.; Lundy, M.W.; Ebetino, F.H.; Coxon, F.P., 2012: Influence of bone affinity on the skeletal distribution of fluorescently labeled bisphosphonates in vivo. Bisphosphonates are widely used antiresorptive drugs that bind to calcium. It has become evident that these drugs have differing affinities for bone mineral; however, it is unclear whether such differences affect their distribution on mineral surf...

Wilkinson, T.J.; Frampton, C.M., 2003: Assessing performance in final year medical students. Can a postgraduate measure be used in an undergraduate setting?. Medical Education 37(3): 233-240

Péterffy, A.; Békássy, S.M.; Vojth, L.; Vaszily, M.; Homolay, P., 1987: Clinical experience with the Björk-Shiley integral monostrut heart valve prosthesis in the aortic and mitral position. From May 1982 to May 1985, 174 Björk-Shiley integral monostrut (BSIM) heart valve prostheses were implanted in 160 patients. Eighty-eight valves were placed in mitral and 86 in aortic position. There were 92 males and 78 females with a mean age o...

Weaver, M.N.; Yang, Y.; Merz, K.M., 2010: Assessment of the CCSD and CCSD(T) coupled-cluster methods in calculating heats of formation for Zn complexes. Heats of formation were calculated using coupled-cluster methods for a series of zinc complexes. The calculated values were evaluated against previously conducted computational studies using density functional methods as well as experimental value...

Miller, Mathew G.; Johnson, Alexander D., 2002: White-opaque switching in Candida albicans is controlled by mating-type locus homeodomain proteins and allows efficient mating. Discovered over a decade ago, white-opaque switching in the human fungal pathogen Candida albicans is an alternation between two quasistable, heritable transcriptional states. Here, we show that white-opaque switching and sexual mating are both co...