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Spectrophotometric determination of clofibrate

, : Spectrophotometric determination of clofibrate. Talanta 34(3): 365-366

A sensitive method for the rapid and accurate determination of clofibrate by hydroxamic acid formation is described. Hydroxylamine hydrochloride is reacted with clofibrate in alkaline medium to give 4-chlorophenoxyisobutyrohydroxamic acid, which forms a purple complex with iron(III) in acidic medium. Common excipients do not interfere.

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Accession: 006460338

PMID: 18964315

DOI: 10.1016/0039-9140(87)80048-6

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