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Spectrophotometric determination of menadione and menadione sodium bi sulfite


Spectrophotometric determination of menadione and menadione sodium bi sulfite



Journal of the Association of Official Analytical Chemists 65(1): 141-143



ISSN/ISBN: 0004-5756

A spectrophotometric method is described for the determination of menadione and menadione sodium bisulfite [Vitamin K analogs] in bulk and in solution for injection. The method measures the intensity of the violet color (.lambda.max [maximum wavelength] 540 nm) developed when menadione reacts with thiosemicarbazide in alkaline medium. Beer's law is obeyed in the concentration range 4-40 .mu.g/ml (r = 0.9995). The method is simple, sensitive and particularly suited for routine analysis of official menadione sodium bisulfite injection. Results are comparable with the USP method.

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Accession: 006460441

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Related references

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