+ Site Statistics
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Spectrophotometric screening method for acetaminophen in serum and plasma

, : Spectrophotometric screening method for acetaminophen in serum and plasma. Clinical Chemistry 26(1): 69-71

A simple, economical procedure for rapidly detecting acetaminophen, an analgesic antipyretic, in serum or plasma is described. The method is based on the reduction by the drug of ferric 2,4,6-tris(2-pyridyl)-s-triazine, at an acidic pH, to ferrous 2,4,6-tris(2-pyridyl)-S-triazine complex, which absorbs maximally at 593 nm. Absorbance and acetaminophen concentration are linearly related from 25-400 mg/l, and so therapeutic and toxic concentrations can be measured. The method is accurate; day-to-day CV [coefficient of variation] for 2 pooled control specimens (103 and 227 mg/l) were 4.4 and 6.6%. Correlation studies, with an established nitration method and with the free-radical diphenylpicrylhydrazyl dye method, showed correlation coefficients of 0.985 and 0.915, respectively. Of 25 commonly used drugs tested, only levodopa, oxyphenylbutazone and phenylephrine interfere significantly. Interference from salicylate, salicylamide and phenylbutazone was insignificant.

(PDF 0-2 workdays service)

Order PDF Full Text


Click here to order any other PDF Full Text

Accession: 006460747

PMID: 7356576

PDF Full Text: Submit

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Other references

Uchio, Y.; Toyota, J.; Nozaki, H.; Nakayama, M.; Nishizono, Y.; Hase, T., 1981: Lobohedleolide and (7Z)-lobohedleolide, new cembranolides from the soft coral Lobophytum hedleyi Whitelegge. The structures of lobohedleolide (1) and (7Z)-lobohedleolide (2), two new cembranolides containing the ,-unsaturated carboxylic acid system isolated from the Japanese soft coral Lobophytum hedleyi Whitelegge, were elucidated from spectral and chem...

Antweiler, H., 1977: Silymarin and polyvinylpyridine-N-oxide as experimental antagonists of the intoxication by Amanita phalloides or its single toxins. Results indicate that silymarin protects plasma membranes against the attack of various toxic principles.

Grunberg, K., 1915: Zoologische Ergebnisse der Expedition des Herrn G. Tessmann nach Sudkamerun und Spanisch-Guinea. Diptera, 1. Stratiomyidae Mitt zool Mus Berlin, 8 41-70

Crimail, P., 1959: Determination of foetal oxygen. Presse Med 67(44): 1662

Kula, C.; Forster, R.; Joermann, G.; Ehle, H., 1998: Effects of plant protection products on terrestrial non-target organisms. Vogt, H [Author] [Communications from the Federal Biological Institute for Agriculture and Forestry Berlin-Dahlem; 100 years research in plant protection: Plant protection and environment] Mitteilungen aus der Biologischen Bundesanstalt fuer Land- und Forstwirtschaft Berlin-Dahlem; 100 years research in plant protection: Plant protection and environment 35-42

Reynier M.; Monier R., 1968: The ribosomes of escherichia coli iii study of the reversible dissociation of rna 5 s by lithium chloride. Bulletin de la Societe de Chimie Biologique 50(10): 1583-1600

Gururaja Rao G.; Rajeswara Rao G., 1981: Pigment composition and chlorophyllase activity in pigeon pea cajanus indicus and gingelly sesamum indicum under sodium chloride salinity. Changes in total chlorophyll [chl.], chl. a and b and total carotenoids and chlorophyllase activity were investigated in pigeon pea and gingelly leaves under NaCl salinity (0.4%; 68.4 meq). Salinity of the soil induced reduction in chlorophyll and...

Kakkar, V. V.; Samama, M. M., 1998: 5th International Symposium on Thromboembolic Diseases. Haemostasis 28(SUPPL 3): 1-151, Nov

Thiery, Isabelle; Nicolas, Luc; Rippka, Rosmarie, 1991: Selection of cyanobacteria isolated from mosquito breeding sites and a potential food source for mosquito larvae. Applied and Environmental Microbiology 57: 54-9

Delany, I. R.; Walsh, U. F.; Ross, I.; Fenton, A. M.; Corkery, D. M.; O'gara, F., 2001: Enhancing the biocontrol efficacy of Pseudomonas fluorescens F113 by altering the regulation and production of 2,4-diacetylphloroglucinol: Improved Pseudomonas biocontrol inoculants. Pseudomonas fluorescens F113 is an effective biocontrol agent against Pythium ultimum, the causative agent of damping-off of sugarbeet seedlings. Biocontrol is mediated via the production of the anti-fungal metabolite 2,4-diacetylphloroglucinol (P...