EurekaMag.com logo
+ Site Statistics
References:
47,893,527
Abstracts:
28,296,643
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Spectroscopic studies of cutaneous photo sensitizing agents 2. spin trapping of photolysis products from sulfanilamide and 4 amino benzoic acid using 5 5 di methyl 1 pyrroline 1 oxide


, : Spectroscopic studies of cutaneous photo sensitizing agents 2. spin trapping of photolysis products from sulfanilamide and 4 amino benzoic acid using 5 5 di methyl 1 pyrroline 1 oxide. Photochemistry and Photobiology 34(2): 147-156

Photodecomposition of sulfanilamide [an antibacterial drug], 4-aminobenzoic acid [a component of sunscreen preparations] and related analogs in aqueous solution was studied with spin traps 5,5-dimethyl-1-pyrroline-1-oxide (DMPO) and CH3NO2 and, by direct ESR techniques. The .ovrhdot.NH2 radical was trapped by DMPO during the photolysis of aqueous solutions of sulfanilamide with a Xe arc lamp. Studies with [15N1]-sulfanilamide indicated that the .ovrhdot.NH2 radical was generated by homolytic fission of the S-N bond. Under the same conditions DMPO trapped the H. and SO3.- radicals during photolysis of sulfanic acid. Direct photolysis of sulfanilamide, sulfanilic acid and Na2SO3 in the absence of any spin trap yielded the SO3.- radical. Photolysis of 4-aminobenzoic acid at pH 7 gave the H. radical which was trapped by DMPO. At low pH values OH. and .ovrhdot.C6H4 COOH radicals were generated during the photolysis of 4-aminobenzoic acid. No eaq- [aqueous electrons] were trapped by CH3NO2 when acid (pH 4) and neutral aqueous solutions of sulfanilamide or 4-aminobenzoic acid were photoirradiated. Mechanism of formation of known photoproducts from the free radicals generated by sulfanilamide and 4-aminobenzoic acid during irradiation are discussed. The free radicals generated by these agents may play an important role in their phototoxic and photoallergic effects in animals.


Accession: 006461011

Submit PDF Full Text: Here


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Related references

Chignell, C.F.; Kalyanaraman, B.; Mason, R.P.; Sik, R.H., 1980: Spectroscopic studies of cutaneous photo sensitizing agents 1. spin trapping of photolysis products from sulfanilamide 4 amino benzoic acid and related compounds. The photodecomposition of sulfanilamide, 4-aminobenzoic acid and other related analogs was studied with the aid of the spin trap 2-methyl-2-nitrosopropane. UV photolysis of an aqueous solution of sulfanilamide yielded the following radicals .ovrhd...

Motten, A.G.; Chignell, C.F., 1983: Spectroscopic studies of cutaneous photo sensitizing agents 3. spin trapping of photolysis products from sulfanilamide analogs. The photodecomposition of sulfanilamide (4-aminobenzenesulfonamide), sulfacetamide, sulfathiazole, sulfadiazine, carbutamide and tolbutamide was studied using the spin traps 2-methyl-2-nitrosopropane and 5,5-dimethyl-1-pyrroline-1-oxide. The follo...

Motten, A.G.; Chignell, C.F., 1983: Spectroscopic studies of cutaneous photosensitizing agents--III. Spin trapping of photolysis products from sulfanilamide analogs. Photochemistry and Photobiology 37(1): 17-26

Fischer, V.; Harrelson, W.G.J. ; Chignell, C.F.; Mason, R.P., 1984: Spectroscopic studies of cutaneous photo sensitizing agents 5. spin trapping and direct esr investigations of the photo reduction of gentian crystal violet. The photolysis of gentian violet (crystal violet) [a compound widely used in medicine, known to be genotoxic] was studied in aqueous solution by ESR spectroscopy. The photoreduction of gentian violet to the semireduced carbon-centered radical was...

Chignell, C.F.; Sik, R.H., 1989: Spectroscopic studies of cutaneous photosensitizing agents--XIV. The spin trapping of free radicals formed during the photolysis of halogenated salicylanilide antibacterial agents. Several antibacterial halogenated salicylanilides, including 3,3',4',5-tetrachlorosalicylanilide (TCSA) and 3,4',5-tribromosalicylanilide (TBSA) are known to cause photoallergy. We have carried out photochemical and spin trapping st...

Li, A.S.W.; Chignell, C.F., 1987: Spectroscopic studies of cutaneous photosensitizing agents ix. a spin trapping study of the photolysis of amiodarone and deethylamiodarone. The photolysis of amiodarone (AM) and its major metabolite mono-N-desethylamiodarone (DEA), has been studied by absorption spectroscopy, electron spin resonance spectroscopy (spin trapping) and oxygraph measurements. Changes in the absorption spec...

Li, A.S.; Chignell, C.F., 1987: Spectroscopic studies of cutaneous photosensitizing agents--IX. A spin trapping study of the photolysis of amiodarone and desethylamiodarone. The photolysis of amiodarone (AM) and its major metabolite mono-N-desethylamiodarone (DEA), has been studied by absorption spectroscopy, electron spin resonance spectroscopy (spin trapping) and oxygraph measurements. Changes in the absorption spec...

Li, A.S.; Chignell, C.F., 1987: Spectroscopic studies of cutaneous photosensitizing agents--XI. Photolysis of chlorpromazine metabolites: a spin-trapping study. Photochemistry and Photobiology 45(6): 695-701

Li, A.S.; Chignell, C.F., 1987: Spectroscopic studies of cutaneous photosensitizing agents--XII. Spin trapping study of the free radicals generated during the photolysis of photoallergens bithionol and fentichlor. Photochemistry and Photobiology 46(4): 445-452

Motten, A.G.; Chignell, C.F.; Mason, R.P., 1983: Spectroscopic studies of cutaneous photo sensitizing agents 6. identification of the free radicals generated during the photolysis of musk ambrette musk xylene and musk ketone. Musk ambrette (4-tert-butyl-3-methoxy-2,5-dinitrotoluene), a common component of perfumes, soaps and some food flavorings, can cause cutaneous photosensitization reactions including photoallergy [in humans]. These may be mediated through free radi...