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Spectrum of in vivo and in vitro cell mediated immune responses in coccidioido mycosis


Cellular Immunology 31(1): 130-141
Spectrum of in vivo and in vitro cell mediated immune responses in coccidioido mycosis
The cell-mediated immune responses of 12 healthy, coccidioidin skin-test positive subjects (Group I) were compared with those of 15 healthy, coccidioidin skin-test positive persons who had primary asymptomatic coccidiodomycosis, (Group II), 12 patients with active, pulmonary coccidioidomycosis (Group III), 4 patients with disseminated disease (Group IV), and 5 patients who were in clinical remission for 1 yr or longer (Group V). Lymphocytes from healthy subjects in Groups I and II responded in vitro to Coccidioides immitis antigen by undergoing increased DNA synthesis (lymphocyte transformation) and/or by producing macrophage migration inhibitory factor (MIF). Patients in Groups III and IV failed to respond to Coccidioides antigens in vivo (skin tests) or in vitro (lymphocyte transformation and production of MIF). The responses of subjects in Group V with inactive disease fell in between those of healthy donors in Groups I and II and patients in Groups III and IV. The cellular immune defect, in terms of antigen recognition, appeared to be specific for C. immitis in all but 1 patient.


Accession: 006461219

PMID: 141334



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