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Spectrum subtraction technique for minimizing extracranial influence on cerebral blood flow measurements by xenon 133 inhalation

, : Spectrum subtraction technique for minimizing extracranial influence on cerebral blood flow measurements by xenon 133 inhalation. Stroke 8(3): 380-382

Estimates of regional cerebral blood flow (rCBF) by the 133Xe inhalation method are influenced by isotope contamination from slow clearing extracerebral tissues. Subtraction of X-ray (31 keV) from .gamma.-ray counts (81 keV) was suggested as a means of yielding clearance curves that are relatively free of such contamination. rCBF measurements based on the total 133Xe spectrum (X-ray plus .gamma.) were compared with those derived from the subtracted spectrum (X-ray minus .gamma.) in 20 young people, using a 2-compartmental analysis of the clearance curves. In comparison with addition, the subtraction data gave substantially higher estimates of blood flow for the slow (2nd) compartment. This, along with a shift in the relative weights of the 2 compartments, indicated a decreased contribution of slow tissue components, consistent with a reduction in extracerebral contamination. Blood flow values obtained by subtraction were in good agreement with those reported for the intracarotid injection method. A limitation of the subtraction technique, however, is the relatively high dose of isotope required for adequate signal-to-noise ratios.

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