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Spectrum subtraction technique for minimizing extracranial influence on cerebral blood flow measurements by xenon 133 inhalation

Spectrum subtraction technique for minimizing extracranial influence on cerebral blood flow measurements by xenon 133 inhalation

Stroke 8(3): 380-382

Estimates of regional cerebral blood flow (rCBF) by the 133Xe inhalation method are influenced by isotope contamination from slow clearing extracerebral tissues. Subtraction of X-ray (31 keV) from .gamma.-ray counts (81 keV) was suggested as a means of yielding clearance curves that are relatively free of such contamination. rCBF measurements based on the total 133Xe spectrum (X-ray plus .gamma.) were compared with those derived from the subtracted spectrum (X-ray minus .gamma.) in 20 young people, using a 2-compartmental analysis of the clearance curves. In comparison with addition, the subtraction data gave substantially higher estimates of blood flow for the slow (2nd) compartment. This, along with a shift in the relative weights of the 2 compartments, indicated a decreased contribution of slow tissue components, consistent with a reduction in extracerebral contamination. Blood flow values obtained by subtraction were in good agreement with those reported for the intracarotid injection method. A limitation of the subtraction technique, however, is the relatively high dose of isotope required for adequate signal-to-noise ratios.

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