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Speculation as to the phenotypic basis of hetero zygous advantage


, : Speculation as to the phenotypic basis of hetero zygous advantage. Speculations in Science & Technology 4(1): 45-50

Evidence of single-locus heterosis in a variety of organisms, especially man, exists but no general mechanism that accounts for this advantage is known. A model is presented to explain heterozygous advantage. It is consistent with known principles of enzyme action and gene regulation. It does not imply that every locus should display such an advantage and the model can be used to explain an advantage in loci with functional and non-functional variant alleles.

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