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Sperm forward motility protein: tissue distribution and species cross reactivity


, : Sperm forward motility protein: tissue distribution and species cross reactivity. Biology of Reproduction 20(2): 247-252

Spermatozoa from the bovine caput epididymidis develop progressive motility when they are incubated with a cyclic[c]AMP phosphodiesterase inhibitor and bovine seminal plasma. Using a photomicrographic motility assay, the distribution of the factor (or factors) that produce this motility in a variety of bovine fluids and tissues was determined. The factor is present almost exclusively in reproductive tract fluids. The species cross reactivity of the seminal plasma motility factor was studied. Bovine caput sperm were stimulated to high levels of forward motility by the seminal plasma of all the mammalian species tested, including monkey, man, dog, rabbit, pig and elephant. This species cross reactivity was apparent in the ability of bovine seminal plasma to produce forward motility in the caput sperm from a number of mammals, including dog, cat, guinea pig, rabbit, bear and monkey. The mechanism of development of the capacity for progressive motility of sperm, which occurs during epididymal transit, may depend on at least 2 factors, i.e., increased changes in intrasperm cAMP levels and the binding of a forward motility protein. These elements may be common to many mammalian species.

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Accession: 006461742

PMID: 110363

DOI: 10.1095/biolreprod20.2.247

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Related references

Hoskins, D.D.; Johnson, D.; Brandt, H.; Ascott, T.S., 1979: Evidence for a role for a forward motility protein in the epididymal development of sperm motility. This review of work on the bull indicates that the initiation of sperm motility involves at least 2 events, viz. an increase in the content of cyclic AMP in spermatozoa during epididymal transport, and the production by the epididymis of a specifi...

Acott, T.S.; Hoskins, D.D., 1983: Cinematographic analysis of bovine epididymal sperm motility: epididymal maturation and forward motility protein. Journal of Submicroscopic Cytology 15(1): 77-82

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Hoskins D.D., 1980: Bovine sperm forward motility protein initial mechanistic studies. Federation Proceedings: Abstract 2632

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